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ABL1 Produkte

(C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9\;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008].

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Ausgewählte ABL1 Kategorien

ABL1 Antikörper

High quality antibodies with extensive validation data.

ABL1 ELISA Kits

Reliable ELISA kits for a wide range of species.

ABL1 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene ABL1 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC, IF
Validierungen
  • (6)
Kat. Nr. ABIN3020872
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IF, IHC (p), DB
Validierungen
  • (1)
  • (4)
Kat. Nr. ABIN6241067
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human, Monkey, Mouse, Rat
Applikation WB, ELISA, IF, ICC
Validierungen
  • (1)
  • (4)
Kat. Nr. ABIN6256686
Menge 100 μL
Datenblatt Datenblatt

Empfohlene ABL1 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
  • (3)
Kat. Nr. ABIN6730567
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6975039
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validierungen
Kat. Nr. ABIN1380761
Menge 2 x 96 tests
Datenblatt Datenblatt

Empfohlene ABL1 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN2565131
Menge 25 μg
Datenblatt Datenblatt
Reaktivität Human
Source Baculovirus infected Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN7317077
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (2)
  • (1)
Kat. Nr. ABIN1047855
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren ABL1 Produkten

OConnell, Kamenyeva, Lustigman, Bell, Nutman: "Defining the target and the effect of imatinib on the filarial c-Abl homologue." in: PLoS neglected tropical diseases, Vol. 11, Issue 7, pp. e0005690, (2017) (PubMed).

Ruan, Su, Shao, Wang, Dong, Huang, Ren: "A sensitive and microscale method for drug screening combining affinity probes and single molecule fluorescence correlation spectroscopy." in: The Analyst, Vol. 140, Issue 4, pp. 1207-14, (2015) (PubMed).

Giordano, Darley-Usmar, Zhang: "Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease." in: Redox biology, Vol. 2, pp. 82-90, (2015) (PubMed).

Chen, Wang, Tang, Fang, Li, Chen, Wang: "Altered expression of c-Abl in patients with epilepsy and in a rat model." in: Synapse (New York, N.Y.), Vol. 68, Issue 7, pp. 306-16, (2014) (PubMed).

Asmussen, Lasater, Tajon, Oses-Prieto, Jun, Taylor, Burlingame, Craik, Shah: "MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction." in: Cancer discovery, Vol. 4, Issue 2, pp. 200-15, (2014) (PubMed).

Sun, Chen, Zhang, Xie, Hou, Hui, Xu, Du, Zhou, Su, Gao: "Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway." in: Scientific reports, Vol. 4, pp. 6527, (2014) (PubMed).

Yang, Roselli, Patchev, Yu, Almeida: "Non-receptor-tyrosine kinases integrate fast glucocorticoid signaling in hippocampal neurons." in: The Journal of biological chemistry, Vol. 288, Issue 33, pp. 23725-39, (2013) (PubMed).

Saluste, Albarran, Alvarez, Rabal, Ortega, Blanco, Kurz, Salgado, Pevarello, Bischoff, Pastor, Oyarzabal: "Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors." in: PLoS ONE, Vol. 7, Issue 10, pp. e45964, (2012) (PubMed).

Neely, Green, LaFerla: "Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 8, pp. 2781-91, (2011) (PubMed).

Lu, Finnis, Xiang, Lee, Markowitz, Okhrimenko, Brodie: "Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells." in: Biochemical and biophysical research communications, Vol. 352, Issue 2, pp. 431-6, (2006) (PubMed).

Synonyme und alternative Namen zu ABL1

ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1), c-abl oncogene 1, non-receptor tyrosine kinase (Abl1), ABL proto-oncogene 1, non-receptor tyrosine kinase (Abl1), Tyrosine-protein kinase abl-1 (abl-1), c-abl oncogene 1, non-receptor tyrosine kinase (abl1), ABL, Abl, AI325092, bcr/abl, c-ABL, c-Abl, E430008G22Rik, JTK7, p150, v-abl

Bezeichner auf Proteinebene für ABL1

  • Abelson tyrosine-protein kinase 1
  • bcr/c-abl oncogene protein
  • c-abl oncogene 1, receptor tyrosine kinase
  • proto-oncogene c-Abl
  • proto-oncogene tyrosine-protein kinase ABL1
  • tyrosine-protein kinase ABL1
  • v-abl Abelson murine leukemia viral oncogene homolog 1
  • Abelson murine leukemia oncogene
  • abelson murine leukemia viral oncogene homolog 1
  • p150
  • v-abl Abelson murine leukemia oncogene 1
  • Abelson murine leukemia viral (v-abl) oncogene homolog 1
  • v-abl Abelson murine leukemia viral oncogene 1
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