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Amylin/DAP Produkte

(Islet Amyloid Polypeptide (IAPP))

Amylin, also known as islet amyloid polypeptide (IAPP), is a peptide hormone primarily produced by pancreatic beta cells. It plays several important roles in regulating glucose metabolism and satiety. Here are the major cellular mechanisms in which amylin is involved:

  • Glucose Regulation and Delayed Absorption: Amylin helps regulate blood glucose levels by slowing down the emptying of the stomach, delaying glucose absorption, and reducing post-meal blood sugar spikes.
  • Appetite Control and Satiety: Amylin acts in the brain to induce feelings of fullness and reduce food intake, contributing to appetite control and weight management.
  • Inhibition of Glucagon and Insulin Sensitivity: Amylin inhibits glucagon secretion, helping to maintain glucose homeostasis, and may enhance insulin sensitivity in peripheral tissues, aiding in overall metabolic health.

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Ausgewählte Amylin/DAP Kategorien

Amylin/DAP Antikörper

High quality antibodies with extensive validation data.

Amylin/DAP ELISA Kits

Reliable ELISA kits for a wide range of species.

Amylin/DAP Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Amylin/DAP Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC, IP, ICC
Validierungen
  • (4)
Kat. Nr. ABIN7426055
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation ELISA, WB, IHC, IF, ICC
Validierungen
  • (3)
Kat. Nr. ABIN6259921
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, WB, IHC
Validierungen
  • (2)
Kat. Nr. ABIN7157084
Menge 100 μg
Datenblatt Datenblatt

Empfohlene Amylin/DAP ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Rat
Analytical Method Quantitative Competition ELISA
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN6957220
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6968064
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6968062
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Amylin/DAP Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7123638
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1307318
Menge 25 μg
Datenblatt Datenblatt
Reaktivität Rat
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7392188
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Amylin/DAP Produkten

Rosas, Nagaraja, Kaur, Panossian, Wickman, Garcia, Al-Khamis, Asea: "Hsp72 (HSPA1A) Prevents Human Islet Amyloid Polypeptide Aggregation and Toxicity: A New Approach for Type 2 Diabetes Treatment." in: PLoS ONE, Vol. 11, Issue 3, pp. e0149409, (2016) (PubMed).

El Assar, Angulo, Santos-Ruiz, Moreno, Novials, Villanueva-Peñacarrillo, Rodríguez-Mañas: "Differential effect of amylin on endothelial-dependent vasodilation in mesenteric arteries from control and insulin resistant rats." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120479, (2015) (PubMed).

Guan, Chow, Song, Verma, Despa, Hersh: "The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells." in: PLoS ONE, Vol. 10, Issue 7, pp. e0133263, (2015) (PubMed).

Ladiwala, Bhattacharya, Perchiacca, Cao, Raleigh, Abedini, Schmidt, Varkey, Langen, Tessier: "Rational design of potent domain antibody inhibitors of amyloid fibril assembly." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 49, pp. 19965-70, (2012) (PubMed).

Gurlo, Ryazantsev, Huang, Yeh, Reber, Hines, OBrien, Glabe, Butler: "Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway." in: The American journal of pathology, Vol. 176, Issue 2, pp. 861-9, (2010) (PubMed).

Zhao, Guan, Lee, Sui, He, Siu, Tse, Tong, Lai, Chan: "Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition." in: Pancreas, Vol. 39, Issue 6, pp. 843-6, (2010) (PubMed).

Zheng, Ren, Zhang, Liu, Li, Li, Yang, He, Su, Li: "Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus." in: Acta diabetologica, Vol. 47, Issue 3, pp. 265-70, (2010) (PubMed).

Nakamura, Okabayashi, Ageyama, Koie, Sankai, Ono, Fujimoto, Terao: "Transthyretin amyloidosis and two other aging-related amyloidoses in an aged vervet monkey." in: Veterinary pathology, Vol. 45, Issue 1, pp. 67-72, (2008) (PubMed).

Zhao, Sui, Guan, He, Gu, Wong, Baum, Lai, Tong, Chan: "Amyloid oligomers in diabetic and nondiabetic human pancreas." in: Translational research : the journal of laboratory and clinical medicine, Vol. 153, Issue 1, pp. 24-32, (2008) (PubMed).

Bhattacharya, Latha, Kumresan, Singh: "Cloning and expression of human islet amyloid polypeptide in cultured cells." in: Biochemical and biophysical research communications, Vol. 356, Issue 3, pp. 622-8, (2007) (PubMed).

Synonyme und alternative Namen zu Amylin/DAP

islet amyloid polypeptide (IAPP), islet amyloid polypeptide (Iapp), Amylin, DAP, IAP, LOC100230121

Bezeichner auf Proteinebene für Amylin/DAP

  • Islet amyloid polypeptide (diabetes-associated peptide; amylin)
  • amylin
  • diabetes-associated peptide
  • insulinoma amyloid peptide
  • DAP
  • islet amyloid polypeptide
  • amyloid protein
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