Huntingtin Antikörper (pSer421)

Produktnummer ABIN100604

Produktdetails anti-Huntingtin Antikörper

Target: Huntingtin (HTT)

Bindungsspezifität: AA 416-424, pSer421

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Huntingtin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Sterilität: Sterile filtered

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding aa 416-424 of Human huntingtin protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Anti-Huntingtin pS421 antibody has been tested for use in ELISA, immunohistochemistry and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect bands at approximately 350 kDa and 200 kDa in size corresponding to full-length Huntingtin protein and truncated (hypothetical) Huntingtin protein, respectively, by western blotting in the appropriate cell lysate or extract.   This antibody is specific for the phosphorylated form of Huntingtin protein at the pS421 residue.  The identity of lower molecular bands ~130 kDa is not known.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.6 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu Huntingtin

Target: Huntingtin (HTT)

Andere Bezeichnung: Huntington (HTT Produkte)

Synonyme: HTT antikoerper, hd antikoerper, ZHD antikoerper, CG9995 antikoerper, Dmel\\CG9995 antikoerper, HD antikoerper, Hsap\\HD antikoerper, Htt antikoerper, dHtt antikoerper, dhtt antikoerper, SLC6A4 antikoerper, huntington antikoerper, it15 antikoerper, htt antikoerper, IT15 antikoerper, AI256365 antikoerper, C430023I11Rik antikoerper, Hd antikoerper, Hdh antikoerper, huntingtin antikoerper, HTT antikoerper, htt antikoerper, LOC373520 antikoerper, Htt antikoerper

Hintergrund: Huntingtin (also known as Huntington's disease protein, Htt and HD protein) is the protein product of a disease gene linked to Huntington's disease, a neuro-degenerative disorder characterized by loss of striatal neurons. This may be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product (see partial protein sequence below). The huntingtin gene locus is large, spanning 180 kb and consisting of 67 exons.  It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. Normal huntingtin protein shows a cytoplasmic localization.  This protein is widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation.
Synonyms: AI256365 antibody, C430023I11Rik antibody, HD antibody, HD protein antibody, HDH antibody, HTT antibody, HUNTINGTON CHOREA antibody, Huntington disease protein antibody, Huntingtin protein antibody, IT15,

Gen-ID: 3064

UniProt: P42858

Pathways: PI3K-Akt Signalweg, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport