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ACR-Modified Keyhole-Lympet Hemocyanine Antikörper

IHC Wirt: Maus Monoclonal 5F6 unconjugated
Produktnummer ABIN1020376
  • Target
    ACR-Modified Keyhole-Lympet Hemocyanine
    Wirt
    Maus
    Klonalität
    Monoklonal
    Applikation
    Immunohistochemistry (IHC)
    Spezifität
    Specific for ACR-modified protein (especially FDP-lysine type derivative).
    Aufreinigung
    Protein A purified
    Klon
    5F6
    Isotyp
    IgG1 kappa
  • Applikationshinweise
    Recommended antibody concentration is 0.5-1.0 µg/mL on paraformaldehyde fixed tissue.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Frozen
    Buffer
    100 µg/mL antibody in 10mM PBS containing 0.1% NaN3 and 0.5% BSA
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Sugiyama, Sun, Nishinohara, Fujita, Masuda, Ochi, Takeuchi: "Expressions of lipid oxidation markers, N(ε)-hexanoyl lysine and acrolein in cisplatin-induced nephrotoxicity in rats." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Vol. 73, Issue 6, pp. 821-6, (2011) (PubMed).

  • Target
    ACR-Modified Keyhole-Lympet Hemocyanine
    Hintergrund
    Acrolein (ACR) is a representative carcinogenic aldehyde found ubiquitously in the environment and formed endogenously through oxidation reactions, such as lipid peroxidation and myeloperoxidasecatalyzed amino acid oxidation. ACR is highly reactive aldehyde and reacts with lysine residue in protein. The reaction with ACR and lysine residue leads to the formation of numerous numbers of adducts, such as formyl-dehydropiperidino-lysine (FDP-lysine) type derivative. This antibody is specific for the ACR-modified protein, especially FDP-lysine type derivative.
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