CD36 Antikörper (FITC)

Produktnummer ABIN1027674

Produktdetails anti-CD36 Antikörper (FITC)

Target: CD36

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD36 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Spezifität: The mouse monoclonal antibody CB38 (NL07) recognizes an extracellular epitope of CD36 (GPIIIb), a 85-113 kDa integral membrane glycoprotein expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: living human myeloid cells

Klon: CB38

Isotyp: IgM kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

Kommentare:

The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: No reconstitution is necessary.

Buffer: Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.
Avoid prolonged exposure to light.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-CD36 Antikörper (FITC) (ABIN1027674)

Moniuszko, Kowal, Rusak, Pietruczuk, Dabrowska, Bodzenta-Lukaszyk: "Monocyte CD163 and CD36 expression in human whole blood and isolated mononuclear cell samples: influence of different anticoagulants." in: Clinical and vaccine immunology : CVI, Vol. 13, Issue 6, pp. 704-7, (2006) (PubMed).

McKenna, Washington, Aquino, Picker, Kroft: "Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry." in: Blood, Vol. 98, Issue 8, pp. 2498-507, (2001) (PubMed).

Kapinsky, Torzewski, Büchler, Duong, Rothe, Schmitz: "Enzymatically degraded LDL preferentially binds to CD14(high) CD16(+) monocytes and induces foam cell formation mediated only in part by the class B scavenger-receptor CD36." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 21, Issue 6, pp. 1004-10, (2001) (PubMed).

Hoffmann, deCathelineau, Ogden, Leverrier, Bratton, Daleke, Ridley, Fadok, Henson: "Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells." in: The Journal of cell biology, Vol. 155, Issue 4, pp. 649-59, (2001) (PubMed).

Matasić, Dietz, Vuk-Pavlović: "Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells." in: Journal of leukocyte biology, Vol. 66, Issue 6, pp. 909-14, (2000) (PubMed).

Fadok, Warner, Bratton, Henson: "CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 6250-7, (1998) (PubMed).

Alessio, Greco, Primo, Ghigo, Bosia, Tandon, Ockenhouse, Jamieson, Malavasi: "Platelet activation and inhibition of malarial cytoadherence by the anti-CD36 IgM monoclonal antibody NL07." in: Blood, Vol. 82, Issue 12, pp. 3637-47, (1994) (PubMed).

Alessio, Roggero, Bussolino, Saitta, Malavasi: "Characterization of the murine monoclonal antibody NL07 specific for the human thrombospondin receptor (CD36 molecule)." in: Current studies in hematology and blood transfusion, Issue 58, pp. 182-6, (1992) (PubMed).

Alessio, Ghigo, Garbarino, Geuna, Malavasi: "Analysis of the human CD36 leucocyte differentiation antigen by means of the monoclonal antibody NL07." in: Cellular immunology, Vol. 137, Issue 2, pp. 487-500, (1991) (PubMed).

Details zu CD36

Target: CD36

Andere Bezeichnung: CD36 (CD36 Produkte)

Synonyme: BDPLT10 antikoerper, CHDS7 antikoerper, FAT antikoerper, GP3B antikoerper, GP4 antikoerper, GPIV antikoerper, PASIV antikoerper, SCARB3 antikoerper, Fat antikoerper, Scarb3 antikoerper, GPIIIB antikoerper, PAS-4 antikoerper, zgc:92513 antikoerper, CD36 molecule antikoerper, CD36 molecule (thrombospondin receptor) antikoerper, CD36 antikoerper, Cd36 antikoerper, cd36 antikoerper

Hintergrund: CD36 Molecule,CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not by follicular and B1 B cells, and it is rapidly induced on follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similarly to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids.,GPIIIb, GPIV, PAS-4, FAT, Thrombospondin receptor, PASIV

Gen-ID: 948

UniProt: P16671

Pathways: TLR Signalweg, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteine