KLRK1 Antikörper

Produktnummer ABIN1027685

Produktdetails anti-KLRK1 Antikörper

Target: KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KLRK1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Spezifität: The mouse monoclonal antibody 1D11 recognizes an extracellular epitope of CD314 / NKG2D, a 42 kDa C-type lectin-like activating receptor expressed by NK cells, gamma/delta T cells, and CD8+ T cells.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: NKL cell line

Klon: 1D11

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Functional application: Blocking of ligand binding.
Immunohistochemistry: Recommended dilution: 5-10 μg/mL.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Konservierungsmittel: Azide free

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-KLRK1 Antikörper (ABIN1027685)

Valencia, Hernández-López, Martínez, Hidalgo, Zapata, Vicente, Varas, Sacedón: "Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors." in: Journal of leukocyte biology, Vol. 87, Issue 3, pp. 405-14, (2010) (PubMed).

Hasenkamp, Borgerding, Uhrberg, Falk, Chapuy, Wulf, Jung, Trümper, Glass: "Self-tolerance of human natural killer cells lacking self-HLA-specific inhibitory receptors." in: Scandinavian journal of immunology, Vol. 67, Issue 3, pp. 218-29, (2008) (PubMed).

Sangiolo, Martinuzzi, Todorovic, Vitaggio, Vallario, Jordaney, Carnevale-Schianca, Capaldi, Geuna, Casorzo, Nash, Aglietta, Cignetti: "Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: implications for their infusion across major HLA barriers." in: International immunology, Vol. 20, Issue 7, pp. 841-8, (2008) (PubMed).

Ebert, Meuter, Moser: "Homing and function of human skin gammadelta T cells and NK cells: relevance for tumor surveillance." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 7, pp. 4331-6, (2006) (PubMed).

Wu, Groh, Spies: "T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial gamma delta T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 3, pp. 1236-40, (2002) (PubMed).

Wu, Cherwinski, Spies, Phillips, Lanier: "DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells." in: The Journal of experimental medicine, Vol. 192, Issue 7, pp. 1059-68, (2000) (PubMed).

Bauer, Groh, Wu, Steinle, Phillips, Lanier, Spies: "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA." in: Science (New York, N.Y.), Vol. 285, Issue 5428, pp. 727-9, (1999) (PubMed).

Details zu KLRK1

Target: KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))

Andere Bezeichnung: CD314 (KLRK1 Produkte)

Synonyme: KLRK1 antikoerper, NKG2D antikoerper, CD314 antikoerper, D12S2489E antikoerper, KLR antikoerper, NKG2-D antikoerper, D6H12S2489E antikoerper, Nkg2d antikoerper, Nkrp2 antikoerper, killer cell lectin like receptor K1 antikoerper, killer cell lectin-like receptor subfamily K, member 1 antikoerper, NKG2D protein antikoerper, KLRK1 antikoerper, Klrk1 antikoerper, NKG2D antikoerper

Hintergrund: Killer cell lectin like receptor K1,CD314, also known as NKG2D (natural killer receptor G2D) or KLRK1 (killer cell lectin-like receptor subfamily K, member 1), is a homodimeric C-type lectin-like activating receptor and costimulator with type II membrane orientation (C teminus extracellular). CD314 homodimers are associated with DAP10, a membrane adaptor protein that signals similar to CD28 by recruitment of phosphatidylinositol 3-kinase. Engagement of CD314 amplifies antigen-specific T cell responses in CD314-positive T cell populations. In NK cells, CD314 is a primary activating receptor. As CD314 ligands the MHC class-I chain-related proteins A and B (MICA, MICB) and UL16-binding proteins (ULBPs) have been identified.,NKG2D, KLRK1, KLR

Gen-ID: 22914

UniProt: P26718

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process