Integrin beta 3 Antikörper (PE)

Produktnummer ABIN1027701

Produktdetails anti-Integrin beta 3 Antikörper (PE)

Target: Integrin beta 3 (ITGB3)

Reaktivität: Human, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 3 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Spezifität: The mouse monoclonal antibody VIPL2 recognizes an extracellular epitope of CD61, a 90-110 kDa transmembrane glycoprotein of integrin family, expressed on platelets, megacaryocytes, osteoclasts, endothelial cells and other cell types, including leucocytes and smooth muscle cells.

Kreuzreaktivität (Details): Human, Non-Human Primates

Aufreinigung: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Klon: VIPL2

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Kommentare:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: No reconstitution is necessary.

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.
Avoid prolonged exposure to light.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-Integrin beta 3 Antikörper (PE) (ABIN1027701)

Barrett, Dai, Gamberg, Gallant, Grant: "Circulating CD14-CD36+ peripheral blood mononuclear cells constitutively produce interleukin-10." in: Journal of leukocyte biology, Vol. 82, Issue 1, pp. 152-60, (2007) (PubMed).

Williams, Mondal, Agrawal: "The HIV-1 Tat protein enhances megakaryocytic commitment of K562 cells by facilitating CREB transcription factor coactivation by CBP." in: Experimental biology and medicine (Maywood, N.J.), Vol. 230, Issue 11, pp. 872-84, (2005) (PubMed).

Mondal, Williams, Ali, Eilers, Agrawal: "The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells." in: Experimental biology and medicine (Maywood, N.J.), Vol. 230, Issue 9, pp. 631-44, (2005) (PubMed).

Roberts, Woods, Dale, Van Der Sluijs, Norman: "Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins." in: Molecular and cellular biology, Vol. 24, Issue 4, pp. 1505-15, (2004) (PubMed).

Ciarlet, Crawford, Cheng, Blutt, Rice, Bergelson, Estes: "VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment." in: Journal of virology, Vol. 76, Issue 3, pp. 1109-23, (2002) (PubMed).

Dzionek, Fuchs, Schmidt, Cremer, Zysk, Miltenyi, Buck, Schmitz: "BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6037-46, (2000) (PubMed).

Details zu Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Andere Bezeichnung: CD61 (ITGB3 Produkte)

Hintergrund: Integrin subunit beta 3,CD61 (beta3 integrin) is a transmembrane glycoprotein, which associates with CD41 or CD51 Molecules to form heterodimeric adhesion receptores. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. It binds to fibronectin, fibrinogen and von Willebrand factor, and is involved in platelet aggregation. CD51/CD61 complex has similar binding properties and is involved in modulating migration and survival of angiogenic endothelial cells.,integrin beta 3, ITGB3, GP3A

Gen-ID: 3690

UniProt: P05106

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex