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Nuclear Antigen Antikörper

IPO-38 Reaktivität: Maus IHC, IP, ELISA, WB Wirt: Maus Monoclonal IPO-38 unconjugated
Produktnummer ABIN103313
  • Target Alle Nuclear Antigen (IPO-38) Antikörper anzeigen
    Nuclear Antigen (IPO-38)
    Reaktivität
    • 5
    • 3
    • 3
    Maus
    Wirt
    • 5
    Maus
    Klonalität
    • 5
    Monoklonal
    Konjugat
    • 5
    Dieser Nuclear Antigen Antikörper ist unkonjugiert
    Applikation
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA, Western Blotting (WB)
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Sterilität
    Sterile filtered
    Immunogen
    A BALB/c mouse was immunized with spleen cells of a human patient with hairy cell leukemia.
    Immunogentype:Native
    Klon
    IPO-38
    Isotyp
    IgG
  • Applikationshinweise
    This antibody is suitable for ELISA,  immunoprecipitation, western blotting and immunohistochemistry (frozen and formalin/paraffin).  The antibody is reported to recognize a nuclear antigen that is present in the cytoplasm and nuclei of proliferating cells (paraformaldehyde fixed, Triton X-100 permeabilized).  An increase of 400% is observed in cells in mitosis (determined by analysis of K562 cells synchronized with colcemide).  IPO-38 does not block the binding of the Ki-67 antibody.   Tonsilar tissue is typically used as a positive control.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.5 M Sodium Chloride, pH 7.2
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Target
    Nuclear Antigen (IPO-38)
    Andere Bezeichnung
    IPO-38 (IPO-38 Produkte)
    Hintergrund
    The specificity of mAb IPO-38 was demonstrated in different human and murine lymphoid and non-lymphoid cell lines. It does not react with mononuclear cells and granulocytes of healthy donors but does react with nuclei of blood cells of patients with different forms of leukemia and with cells from lymph nodes of patients with Hodgkin's disease and non-hodgkin's lymphoma. Also a positive reaction in nuclei of breast and colorectal tumor cells was demonstrated. IPO-38 may be a good marker of cellular proliferation during monitoring of tumor progression.
    Synonyms: Non-histone chromosomal protein HMG-14 antibody, High-mobility group nucleosome-binding domain-containing protein 1 antibody, HMGN1 antibody, HMG14 antibody
    Gen-ID
    15312
    NCBI Accession
    NP_032277
    UniProt
    P18608
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