alpha 2 Macroglobulin Antikörper

Produktnummer ABIN103762

Produktdetails anti-alpha 2 Macroglobulin Antikörper

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser alpha 2 Macroglobulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: a2-Macroglobulin [Human Plasma]
Immunogentype:Native

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Anti-alpha-2-macroglobulin antibody is suitable for ELISA, Western Blot and Immunohistochemistry applications. Anti-alpha-2-MACROGLOBULIN antibody should be optimized by the end user for the specific reactive conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Restore with deionized water (or equivalent)

Konzentration: 10.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-alpha 2 Macroglobulin Antikörper (ABIN103762)

Chung, Hsu, Chen, Liu, Chang, Li, Huang, Shieh, Lee: "Association of salivary alpha 2-macroglobulin levels and clinical characteristics in type 2 diabetes." in: Journal of diabetes investigation, Vol. 7, Issue 2, pp. 190-6, (2017) (PubMed).

Details zu alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Andere Bezeichnung: Alpha-2-Macroglobulin (A2M Produkte)

Synonyme: A2MD antikoerper, CPAMD5 antikoerper, FWP007 antikoerper, S863-7 antikoerper, A2MAC1 antikoerper, A2m1 antikoerper, A2maa antikoerper, Mam antikoerper, A2mp antikoerper, A2M antikoerper, LOC733429 antikoerper, endod antikoerper, cpamd5 antikoerper, fwp007 antikoerper, s863-7 antikoerper, a2mb antikoerper, endodermin antikoerper, Alpha-2-M antikoerper, alpha-2-macroglobulin antikoerper, pregnancy-zone protein L homeolog antikoerper, alpha-2-macroglobulin S homeolog antikoerper, pregnancy zone protein antikoerper, alpha-2-macroglobulin-like antikoerper, A2M antikoerper, A2m antikoerper, LOC477699 antikoerper, pzp.L antikoerper, AZL_c00450 antikoerper, LOC100349077 antikoerper, a2m antikoerper, LOC100061656 antikoerper, LOC100090399 antikoerper, a2m.S antikoerper, LOC100469973 antikoerper, LOC100595735 antikoerper, PZP antikoerper, LOC100353095 antikoerper, LOC101122940 antikoerper, LOC101801552 antikoerper, LOC100911545 antikoerper

Hintergrund: Alpha-2-Macroglobulin detects Macroglobulin. Alpha-2-MACROGLOBULIN is a large plasma protein found in the blood. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. Alpha 2-Macroglobulin is the largest major nonimmunoglobulin protein in plasma. The alpha 2-macroglobulin molecule is synthesized mainly in liver, but also locally by macrophages, fibroblasts, and adrenocortical cells. Alpha 2 macroglobulin acts as an antiprotease and is able to inactivate an enormous variety of proteinases. It functions as an inhibitor of fibrinolysis by inhibiting plasmin and kallikrein. It functions as an inhibitor of coagulation by inhibiting thrombin. Alpha 2-macroglobulin may act as a carrier protein because it also binds to numerous growth factors and cytokines, such as platelet-derived growth factor, basic fibroblast growth factor, TGF-β, insulin, and IL-1β. No specific deficiency with associated disease has been recognized, and no disease state is attributed to low concentrations of Alpha 2 macroglobulin. The concentration of alpha 2 macroglobulin rises 10-fold or more in the nephrotic syndrome when other lower molecular weight proteins are lost in the urine. The loss of alpha 2 macroglobulin into urine is prevented by its large size. The net result is that alpha 2 macroglobulin reaches serum levels equal to or greater than those of albumin in the nephrotic syndrome, which has the effect of maintaining oncotic pressure. Antialpha-2-macroglobulin is ideal for investigators involved in serum component protein research.
Synonyms: A2M antibody, Alpha 2 M antibody, Alpha 2M antibody, CPAMD5 antibody, DKFZp779B086 antibody, FWP007 antibody, S863 7 antibody

Gen-ID: 2

UniProt: P01023

Pathways: Lipid Metabolism