IDO2 Antikörper

Produktnummer ABIN1043821

Hersteller Produkt- Nr.: 210-301-e59

Produktdetails anti-IDO2 Antikörper

Target: IDO2 (Indoleamine 2,3-Dioxygenase 2 (IDO2))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IDO2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Fluorescence Microscopy (FM)

Hersteller Produkt- Nr.: 210-301-e59

Hersteller: Rockland

Verwendungszweck: IDO2 Antibody

Kreuzreaktivität (Details): IDO2 antibody is specific for mouse IDO2 protein.

Produktmerkmale: Synonyms: mouse anti-IDO2 Antibody, Indoleamine 2,3-dioxygenase 2, Indol1, Indoleamine 2,3-dioxygenase-like protein 1, Indoleamine-pyrrole 2,3-dioxygenase-like protein 1, Ido-2, Ido 2, IDO2 antibody, mouse anti-IDO-2 antibody

Aufreinigung: Anti-IDO2 was purified from concentrated tissue culture supernate by Protein G chromatography followed by extensive dialysis against the buffer stated above.

Sterilität: Sterile filtered

Immunogen:

Immunogen: Anti-IDO2 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with complete mouse IDO2 protein followed by hybridoma development.

Immunogen Type: Recombinant Protein

Klon: 1HC

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise:

Application Note: Anti-IDO2 antibody has been tested in western blot and is suitable for use in ELISA and IF. Specific conditions for reactivity should be optimized by the end user.

Western Blot Dilution: 1:500-1:1500

ELISA Dilution: 1:5000 - 1:50000

IF Microscopy Dilution: 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Referenzen für anti-IDO2 Antikörper (ABIN1043821)

Wolff, Driever, Erdlenbruch, Kortmann, Rutkowski, Pietsch, Parker, Metz, Gnekow, Kramm: "Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol." in: Cancer, Vol. 116, Issue 3, pp. 705-12, (2010) (PubMed).

Metz, Duhadaway, Rust, Munn, Muller, Mautino, Prendergast: "Zinc protoporphyrin IX stimulates tumor immunity by disrupting the immunosuppressive enzyme indoleamine 2,3-dioxygenase." in: Molecular cancer therapeutics, Vol. 9, Issue 6, pp. 1864-71, (2010) (PubMed).

Details zu IDO2

Target: IDO2 (Indoleamine 2,3-Dioxygenase 2 (IDO2))

Andere Bezeichnung: Ido2 (IDO2 Produkte)

Hintergrund: Background: Indoleamine 2,3-dioxygenase 2 (IDO2) is related to IDO1, and may play a role in T and B Cell Immunity. IDO2's role in immune regulation will be become clearer following the completion of genetic knock-out studies. IDO2 is expressed in a few select cell types and levels of protein expression appear to be very low, perhaps below the level of detection by IHC. Small-molecule inhibitors of indoleamine 2,3-dioxygenase (IDO) are currently being translated to clinic for evaluation as cancer therapeutics.

Gen-ID: 209176

NCBI Accession: NP_666061

UniProt: Q8R0V5