ISG15 Antikörper (AA 2-157) (HRP)

Produktnummer ABIN1046251

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ISG15 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ISG15 Antikörper (AA 2-157) (HRP) (ABIN1046251)

Target: ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ISG15 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-ISG15 Antikörper (HRP)

Bindungsspezifität: AA 2-157

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-like protein ISG15 protein (2-157AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid freeze and thaw cycles.
Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ISG15

Target: ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))

Andere Bezeichnung: ISG15

Hintergrund:

Background: Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. Ref.12 Ref.13 Ref.14 Ref.15 Ref.20 Ref.21In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy

Aliases: G1P2 antibody, hUCRP antibody, IFI 15 antibody, IFI15 antibody, Interferon alpha inducible protein antibody, Interferon induced protein 15 antibody, Interferon induced protein IFI-15K antibody, Interferon stimulated protein 15 kDa antibody, Interferon, alpha-inducible protein (clone IFI-15K) antibody, Interferon-induced 15 kDa protein antibody, Interferon-induced 17 kDa protein antibody, Interferon-induced 17- kDa/15- kDa protein antibody, IP17 antibody, ISG 15 antibody, ISG15 antibody, ISG15 ubiquitin like modifier antibody, ISG15_HUMAN antibody, Ubiquitin cross-reactive protein antibody, Ubiquitin-like protein ISG15 antibody, UCRP antibody

UniProt: P05161