TLK1 Antikörper (Isoform 1)

Produktnummer ABIN107632

Produktdetails anti-TLK1 Antikörper

Target: TLK1 (Tousled-Like Kinase 1 (TLK1))

Bindungsspezifität: AA 737-751, Isoform 1

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 737-751 of human Tlk1 (Tousled-like kinase) protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 86 kDa, 89 kDa or 64 kDa in size corresponding to isoforms of TLk-1 by western blotting in the appropriate cell lysate or extract.  This antibody reacts with both phosphorylated and non-phosphorylated forms of Tlk-1 at the S743 residue (isoform 1) of the protein.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.60 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu TLK1

Target: TLK1 (Tousled-Like Kinase 1 (TLK1))

Andere Bezeichnung: Tlk1 (TLK1 Produkte)

Synonyme: PKU-beta antikoerper, 4930545J15Rik antikoerper, fe11e12 antikoerper, si:dkey-251e16.4 antikoerper, tlk1 antikoerper, wu:fe11e12 antikoerper, TLK1 antikoerper, fb76h12 antikoerper, si:dkey-88m1.1 antikoerper, wu:fb76h12 antikoerper, DKFZp459L163 antikoerper, tousled like kinase 1 antikoerper, tousled-like kinase 1 antikoerper, tousled-like kinase 1b antikoerper, tousled like kinase 1 like antikoerper, serine/threonine-protein kinase TOUSLED antikoerper, tousled-like kinase 1a antikoerper, Serine/threonine-protein kinase tousled-like 1 antikoerper, TLK1 antikoerper, Tlk1 antikoerper, tlk1b antikoerper, TLK1L antikoerper, LOC542181 antikoerper, tlk1a antikoerper, tlk1 antikoerper, tlk-1 antikoerper

Hintergrund: Tlk-1 (also known as tousled-like kinase, serine/threonine-protein kinase tousled-like 1 and PKU-beta) is a target for Chk1 upon induction of DNA-damage. Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. Tlk-1 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent.  Tlk-1 heterodimerizes with Tlk-2.  Multiple isoforms of the protein have been detected.  Mature Tlk-1 is reported to have an apparent molecular weight of ~86kDa, ~89kDa and ~64kDa corresponding to isoforms 1, 2 and 3 respectively.
Synonyms: PKU beta antibody, serine threonine protein kinase antibody, Serine/threonine protein kinase tousled like 1 antibody, TLK1 antibody, Tousled like kinase 1 antibody

Gen-ID: 9874, 33636698

UniProt: Q9UKI8