RC3H1 Antikörper (C-Term)
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- Target Alle RC3H1 Antikörper anzeigen
- RC3H1 (Ring Finger and CCCH-Type Domains 1 (RC3H1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser RC3H1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- At least three isoforms of RC3H1 are known to exist, this antibody will detect all three isoforms.
- Aufreinigung
- Affinity chromatography purified via peptide column
- Immunogen
- Rabbit polyclonal RC3H1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human RC3H1.
- Isotyp
- IgG
- Top Product
- Discover our top product RC3H1 Primärantikörper
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- Applikationshinweise
- RC3H1 antibody can be used for detection of RC3H1 by Western blot at 1 - 2 μg/mL.
- Kommentare
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(CT) Ring finger and CCCH-type domains 1
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % Sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Lagerung
- 4 °C/-20 °C
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- Target
- RC3H1 (Ring Finger and CCCH-Type Domains 1 (RC3H1))
- Andere Bezeichnung
- RC3H1 (RC3H1 Produkte)
- Synonyme
- RNF198 antikoerper, ROQUIN antikoerper, RC3H1 antikoerper, si:dkey-192m14.4 antikoerper, 5730557L09Rik antikoerper, Gm551 antikoerper, N28103 antikoerper, mKIAA2025 antikoerper, RGD1563512 antikoerper, rc3h1 antikoerper, ring finger and CCCH-type domains 1 antikoerper, ring finger and CCCH-type domains 1a antikoerper, ring finger and CCCH-type zinc finger domains 1 antikoerper, RING CCCH (C3H) domains 1 antikoerper, ring finger and CCCH-type domains 1 L homeolog antikoerper, RC3H1 antikoerper, rc3h1a antikoerper, Rc3h1 antikoerper, rc3h1.L antikoerper
- Hintergrund
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The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
Synonyms: Ring finger and CCCH-type domains 1, ring finger protein 198, RNF198, roquin - Molekulargewicht
- 125 kDa
- Gen-ID
- 149041
- NCBI Accession
- NP_742068
- Pathways
- Ribonucleoprotein Complex Subunit Organization, Activated T Cell Proliferation
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