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GZMB Antikörper

Name: GZMB Antikörper
SKU: ABIN108719
Price: 396.92 EUR
Availability: InStock

GZMB Reaktivität: Human ELISA, FACS, cELISA Wirt: Maus Monoclonal GM-4C1 unconjugated

Specificity testing of GM4C1. (GZMB Antikörper)

FACS

Intracellular detection of granzyme B in human PBMC Mononuclear cells from peripheral blood (PBMC) were seperated by Ficoll-Hypaque, cultivated for 6h in the presence of phorbolester and ionomycin, fixed and permeabilised. (GZMB Antikörper)

FACS

BOSC cells were transiently transfected with expression vectors for Granzyme A, B, K, or M. (GZMB Antikörper)

FACS

5 Abbildungen

Produktnummer ABIN108719

Datenblatt (PDF)

Target Alle GZMB Antikörper anzeigen

GZMB (Granzyme B (GZMB))
Reaktivität
130

52

25

10

4

2

1

1
Human
Wirt
83

49

3
Maus
Passende Sekundärantikörper
Klonalität
81

54
Monoklonal
Konjugat
78

12

8

4

3

3

3

3

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser GZMB Antikörper ist unkonjugiert
Applikation
72

42

41

35

18

17

16

14

13

9

9

6

6

5

2

2

2

2

1

1

1

1

1
ELISA, Flow Cytometry (FACS), Cell-ELISA (cELISA)

Spezifität

GM4C1 recognises granzyme B transiently expressed on the cell surface of transfected BOSC cells as well as the native protein in peripheral blood mononuclear cells. The antibody does not cross-react with the human granzymes A, K or M (Fi

Aufreinigung

Protein G

Immunogen

genetic immunisation with cDNA encoding human Granzyme B

Klon

GM-4C1

Isotyp

IgG1

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Applikationshinweise

Flow cytometry: 1.2 µg/10^6 cells
ELISA: 1:200 - 1:400
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Buffer

PBS, pH 7.2

Handhabung

Avoid repeated freezing and thawing.

Lagerung

4 °C

Informationen zur Lagerung

short term: 2 °C - 8 °C, long term: -20 °C
Target

GZMB (Granzyme B (GZMB))

Andere Bezeichnung

Granzyme B (GZMB Produkte)

Synonyme

CCPI antikoerper, CGL-1 antikoerper, CGL1 antikoerper, CSP-B antikoerper, CSPB antikoerper, CTLA1 antikoerper, CTSGL1 antikoerper, HLP antikoerper, SECT antikoerper, granzyme B antikoerper, GZMB antikoerper

Hintergrund

Granzymes are exogenous serine proteases that are stored in the cytotoxic granules of activated T cells and NK cells. GM4C1 was generated by genetic immunisation and reacts with human granzyme B (GrB), a 27 kDa serine protease which cleaves target-cell proteins at specific aspartate residues.

UniProt

P10144

Pathways

Apoptose, Caspase Kaskade in der Apoptose