IGF2 Antikörper (AA 25-180)

Produktnummer ABIN1098108

Produktdetails anti-IGF2 Antikörper

Target: IGF2 (Insulin-Like Growth Factor 2 (IGF2))

Bindungsspezifität: AA 25-180

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IGF2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Verwendungszweck: IGF2 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human IGF2 (AA: 25-180) expressed in E. Coli.

Klon: 8H1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-IGF2 Antikörper (ABIN1098108)

El Tayebi, Salah, El Sayed, Salam, Zekri, Zayed, Salem, Esmat, Abdelaziz: "Expression of insulin-like growth factor-II, matrix metalloproteinases, and their tissue inhibitors as predictive markers in the peripheral blood of HCC patients." in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, Vol. 16, Issue 4, pp. 346-54, (2011) (PubMed).

Shetty, Movva, Pasupuleti, Vedicherlla, Vattam, Venkatasubramanian, Ahuja, Hasan: "Regulation of IGF2 transcript and protein expression by altered methylation in breast cancer." in: Journal of cancer research and clinical oncology, Vol. 137, Issue 2, pp. 339-45, (2011) (PubMed).

Details zu IGF2

Target: IGF2 (Insulin-Like Growth Factor 2 (IGF2))

Andere Bezeichnung: IGF2 (IGF2 Produkte)

Hintergrund:

Description: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Aliases: IGF-II, PP9974, C11orf43, FLJ22066, FLJ44734

Molekulargewicht: 20.1kDa

Gen-ID: 3481

HGNC: 3481

UniProt: P01344

Pathways: Hormone Activity, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Carbohydrate Metabolic Process, Activated T Cell Proliferation