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CD59 Antikörper (AA 31-111)

Name: CD59 Antikörper (AA 31-111)
Brand: antibodies-online
SKU: ABIN1098134
Price: 640.59 EUR
Availability: InStock

CD59 Reaktivität: Human FACS, IHC, ELISA, ICC Wirt: Maus Monoclonal 8D2B8 unconjugated

Western blot analysis using CD59 mAb against human CD59 recombinant protein. (CD59 Antikörper (AA 31-111))

Immunofluorescence analysis of MCF-7 cells using CD59 mouse mAb (green). (CD59 Antikörper (AA 31-111))

Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using CD59 mouse mAb with DAB staining. (CD59 Antikörper (AA 31-111))

IHC

Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using CD59 mouse mAb with DAB staining. (CD59 Antikörper (AA 31-111))

IHC

Black line: Control Antigen (100 ng), Purple line: Antigen(10 ng), Blue line: Antigen (50 ng), Red line: Antigen (100 ng), (CD59 Antikörper (AA 31-111))

ELISA

Flow cytometric analysis of HeLa cells using CD59 mouse mAb (green) and negative control (red). (CD59 Antikörper (AA 31-111))

FACS

Western blot analysis using CD59 mAb against HEK293 (1) and CD59 (AA: 31-111)-hIgGFc transfected HEK293 (2) cell lysate. (CD59 Antikörper (AA 31-111))

Immunofluorescence analysis of Hela cells using CD59 mouse mAb (green). (CD59 Antikörper (AA 31-111))

8 Abbildungen

(2 Referenzen)

Produktnummer ABIN1098134

Datenblatt (PDF)

Target Alle CD59 Antikörper anzeigen

CD59
Bindungsspezifität
16

10

8

6

4

4

2

2

2

2

1

1

1

1

1

1

1
AA 31-111
Reaktivität
143

14

9

8

5

3

2

1

1
Human
Wirt
89

73

6

6
Maus
Passende Sekundärantikörper
Klonalität
96

75

1
Monoklonal
Konjugat
78

21

16

14

6

4

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
Dieser CD59 Antikörper ist unkonjugiert
Applikation
101

69

44

42

31

28

27

17

14

13

13

13

11

11

8

3

3

3

1

1

1
Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Verwendungszweck

CD59 Antibody

Aufreinigung

Purified antibody

Immunogen

Purified recombinant fragment of human CD59 (AA: 31-111) expressed in E. Coli.

Klon

8D2B8

Isotyp

IgG1
anti-CD59 (CD59) (AA 74-110) antibody
CD59 Reaktivität: Human FACS, WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB56691 unconjugated

anti-CD59 (CD59) antibody
CD59 Reaktivität: Human, Maus FACS, WB, IP, IHC (p) Wirt: Maus Monoclonal MEM-43-5 unconjugated

anti-CD59 (CD59) antibody
CD59 Reaktivität: Human FACS, IP, IHC (p) Wirt: Maus Monoclonal MEM-43 unconjugated

anti-CD59 (CD59) (AA 31-111) antibody
CD59 Reaktivität: Human FACS, WB, IHC, ELISA, IF/ICC Wirt: Maus Monoclonal unconjugated

anti-CD59 (CD59) (AA 23-105) antibody
CD59 Reaktivität: Ratte WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-CD59 (CD59) (AA 1-128) antibody
CD59 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 3G6 unconjugated

anti-CD59 (CD59) (AA 26-102) antibody
CD59 Reaktivität: Human WB, IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated

anti-CD59 (CD59) antibody (Biotin)
CD59 Reaktivität: Human FACS, IP, IHC (p) Wirt: Maus Monoclonal MEM-43 Biotin

anti-CD59 (CD59) antibody (FITC)
CD59 Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-43 FITC

anti-CD59 (CD59) (AA 52-100) antibody
CD59 Reaktivität: Human FACS, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/50 - 1/200

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Alegretti, Mucenic, Merzoni, Faulhaber, Silla, Xavier: "Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients." in: Cellular immunology, Vol. 265, Issue 2, pp. 127-32, (2010) (PubMed).

Ma, Chang, Qin, Sun, Huang, He: "Decreased expression of complement regulatory proteins, CD55 and CD59, on peripheral blood leucocytes in patients with type 2 diabetes and macrovascular diseases." in: Chinese medical journal, Vol. 122, Issue 18, pp. 2123-8, (2009) (PubMed).
Target

CD59

Andere Bezeichnung

CD59 (CD59 Produkte)

Synonyme

16.3A5 antikoerper, 1F5 antikoerper, EJ16 antikoerper, EJ30 antikoerper, EL32 antikoerper, G344 antikoerper, HRF-20 antikoerper, HRF20 antikoerper, MAC-IP antikoerper, MACIF antikoerper, MEM43 antikoerper, MIC11 antikoerper, MIN1 antikoerper, MIN2 antikoerper, MIN3 antikoerper, MIRL antikoerper, MSK21 antikoerper, p18-20 antikoerper, Cd59a antikoerper, Cd59b antikoerper, MACIP antikoerper, CD59 molecule (CD59 blood group) antikoerper, CD59 molecule antikoerper, CD59 antikoerper, Cd59 antikoerper

Hintergrund

Description: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Aliases: 1F5, EJ16, EJ30, EL32, G344, MIN1, MIN2, MIN3, MIRL, HRF20, MACIF, MEM43, MIC11, MSK21, 16.3A5, HRF-20, MAC-IP, p18-20

Molekulargewicht

14.2kDa

Gen-ID

966

HGNC

966

UniProt

P13987

Pathways

Komplementsystem