MMP2 Antikörper (AA 242-396)

Produktnummer ABIN1098146

Produktdetails anti-MMP2 Antikörper

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Bindungsspezifität: AA 242-396

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: MMP2 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human MMP2 (AA: 242-396) expressed in E. Coli.

Klon: 4D1E2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-MMP2 Antikörper (ABIN1098146)

Langers, Verspaget, Hawinkels, Kubben, van Duijn, van der Reijden, Hardwick, Hommes, Sier: "MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients." in: British journal of cancer, Vol. 106, Issue 9, pp. 1495-8, (2012) (PubMed).

Hajighasemi: "Profiles of MMP-2 expression in Jurkat, Molt-4 and U937 cells." in: Iranian journal of immunology : IJI, Vol. 8, Issue 2, pp. 120-6, (2011) (PubMed).

Details zu MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Andere Bezeichnung: MMP2 (MMP2 Produkte)

Hintergrund:

Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Aliases: CLG4, MONA, CLG4A, TBE-1, MMP-II

Molekulargewicht: 73.8kDa

Gen-ID: 4313

HGNC: 4313

UniProt: P08253

Pathways: Activation of Innate immune Response