CLCN3 Antikörper (AA 98-115)
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- Target Alle CLCN3 Antikörper anzeigen
- CLCN3 (Chloride Channel 3 (CLCN3))
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Bindungsspezifität
- AA 98-115
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Reaktivität
- Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CLCN3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (fixed cells) (IF/ICC)
- Verwendungszweck
- Anti-Chloride Channel Protein 3 Mouse Monoclonal Antibody
- Spezifität
- This antibody recognizes human, mouse, and rat Clcn3. It does not cross-react with Clcn4 or Clcn5.
- Kreuzreaktivität
- Human, Maus, Ratte
- Kreuzreaktivität (Details)
- No cross Reactivity with Cav3.2
- Aufreinigung
- Purified by Protein G affinity chromatography.
- Immunogen
- Synthetic peptide correspond- ing to aa 98-115 (cytoplasmic N-terminus) of rat Clcn3 (accession no. NP_445815.2).
- Klon
- S258-5
- Isotyp
- IgG1
- Top Product
- Discover our top product CLCN3 Primärantikörper
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- Applikationshinweise
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Immunoblotting: use at 1-2 μg/mL. A band of ~90 kDa is detected.
Immunohistochemistry: use at 1-10 μg/mL.
These are recommended concentrations. User should determine optimal concentrations for their application.
Positive control: Rat brain membranes. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Rekonstitution
- Dilute in PBS or medium which is identical to that used in the assay system.
- Konzentration
- Lot specific
- Buffer
- PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- This antibody is stable for at least one (1) year at -20°C.
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- Target
- CLCN3 (Chloride Channel 3 (CLCN3))
- Andere Bezeichnung
- Chloride Channel Protein 3 (Clcn3) (CLCN3 Produkte)
- Synonyme
- CLC3 antikoerper, ClC-3 antikoerper, Clc3 antikoerper, CLCN3 antikoerper, fb78c02 antikoerper, wu:fb78c02 antikoerper, clc3 antikoerper, clc-3 antikoerper, chloride voltage-gated channel 3 antikoerper, chloride channel, voltage-sensitive 3 antikoerper, chloride channel 3 antikoerper, chloride channel protein 3 antikoerper, chloride channel, voltage-sensitive 3 S homeolog antikoerper, CLCN3 antikoerper, Clcn3 antikoerper, clcn3 antikoerper, PTRG_03131 antikoerper, BDBG_05668 antikoerper, MCYG_04420 antikoerper, clcn3.S antikoerper
- Hintergrund
- H(+)/Cl(-) exchange transporter 3,[Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:10915634). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {UniProtKB:P51790, PubMed:10915634}., [Isoform 2]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:10915634). May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C (PubMed:8155321). It could help neuronal cells to establish short-term memory (PubMed:8155321). {PubMed:10915634, PubMed:8155321}.,Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Clcn3 mediates the exchange of chloride ions against protons and functions as an antiporter, contributing to the acidification of the endosome and synaptic vesicle lumen. It may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C.,[Isoform 1]: Lysosome membrane, Late endosome membrane, Cell membrane, Early endosome membrane,Chloride channel protein 3, ClC-3, Chloride transporter ClC-3
- NCBI Accession
- NP_445815
- UniProt
- P51792
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