ACIN1 Antikörper (N-Term)

Produktnummer ABIN1105223

Produktdetails anti-ACIN1 Antikörper

Target: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Bindungsspezifität: AA 1-523, N-Term

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ACIN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Spezifität: This antibody reacts withAcinusL.

Kreuzreaktivität (Details): Species reactivity (tested):Human.
Does not react with mouse (WR19L, NIH3T3) or hamster (CHO).

Aufreinigung: Protein A agarose beads

Immunogen: GST-human AcinusL fusion protein corresponding to N-terminal amino acids (1~523 a.a.)

Klon: 3H8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store (in aliquots) at -20 °C.

Details zu ACIN1

Target: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Andere Bezeichnung: Acinus / ACIN1 (ACIN1 Produkte)

Hintergrund: Chromatin condensation and nuclear fragmentation (CCNF) are hallmarks of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase-activated DNase (CAD/DFF40) and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (Apoptotic Chromatin Condensation Inducer in the Nucleus). The 220 kDa Acinus protein is cleaved by caspase-3 and an additional unknown protease to generate a 17 kDa peptide that which causes chromatin condensation in vitro when added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS, and AcinusS'. Acinus is ubiquitously expressed.Synonyms: Apoptotic chromatin condensation inducer in the nucleus, KIAA0670

Molekulargewicht: 220 kDa

Gen-ID: 22985

NCBI Accession: NP_001158286

UniProt: Q9UKV3