beta Amyloid Antikörper (C-Term)

Produktnummer ABIN1105357

Produktdetails anti-beta Amyloid Antikörper

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta Amyloid Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), ELISA (Detection)

Sequenz: MVGGVVIA

Spezifität: This antibody specifically recognizes the C-terminal sequence of beta amyloid peptide 42 and full length beta amyloid peptide 42. The antibody does not cross react with beta amyloid peptide 40 in dot blotting and ELISA. Cross-reactivity to beta amyloid peptide 43 is less than 1 % in ELISA.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Primates, Mouse, Rat.

Aufreinigung: Protein G affinity purified

Immunogen: KLH conjugated to a short peptide corresponding to the C-terminal sequence of beta amyloid peptide 42

Klon: CA9 10C11

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with Double distillated water is recommended and to adjust the final concentration to 1.0 mg/mL.

Buffer: 0.01 M PBS pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: Amyloid beta (Abeta Produkte)

Hintergrund: Amyloid beta peptide 42 (Aβ42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. Aβ42 and Aβ40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Aβ42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Aβ42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Aβ42 contributes to the pathogenesis of Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. Another is that the neurotoxicity of Aβ42 oligomer is the cause of the disease.

Gen-ID: 351

Pathways: Inflammasome