Tschernig, Janardhan, Pabst, Singh: "Lipopolysaccharide induced inflammation in the perivascular space in lungs." in: Journal of occupational medicine and toxicology (London, England), Vol. 3, pp. 17, (2008) (PubMed).
Rat MCP-1/JE (monocyte chemoattracctant protein-1) is an 148-amino acid CC chemokine with a NH2-terminal sequence of 29 residues as a signal sequence. It was originally cloned from Con A-stimulated rat spleen cDNA library1. This rat MCP-1/JE is 49-amino acid longer than human MCP-1 at 3?-end. This 3?-end is a serine and threonine rich zone, which is probably responsible for the extensive O-glycosylation and which explains for the higher molecular weight (25 kDa)2. In vitro, MCP-1/JE is chemotactic for monocytes as well as lymphocytes and basophils, but not for neutrophils. MCP-1/JE is produced by a wide range of cell types as a reaction to diverse inflammatory stimuli3.