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HLA B7 Antikörper

HLA B7 Reaktivität: Human IHC (p) Wirt: Maus Monoclonal EP-4 unconjugated
Produktnummer ABIN1107562
  • Target Alle HLA B7 Antikörper anzeigen
    HLA B7 (HLA Class I B7 Alpha (HLA B7))
    Reaktivität
    • 13
    • 3
    • 2
    • 2
    • 2
    Human
    Wirt
    • 11
    • 2
    Maus
    Klonalität
    • 11
    • 2
    Monoklonal
    Konjugat
    • 7
    • 4
    • 2
    Dieser HLA B7 Antikörper ist unkonjugiert
    Applikation
    • 10
    • 3
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody clone EP-4 recognizes the HLA-B27 cell surface antigen on Human cells. Since EP-4 recognizes the HLA-B27 antigen, it may be used to HLA type human lymphoctyes. Approximately 60 % of patients with ankylosing spondylitis are HLA-B27 positive. This reagent can be used to help identify this HLA haplotype in Human lymphocytes. Monoclonal antibody EP-4 recognizes the HLA-B27 antigen expressed on individuals with this HLA haplotype.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human.
    Aufreinigung
    Purified
    Immunogen
    Native purified from lymphocytes of HLA-B27 individual.
    Klon
    EP-4
    Isotyp
    IgM
    Top Product
    Discover our top product HLA B7 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.1 mg/mL
    Buffer
    PBS, 0.05 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or -20 °C for longer.
  • Target
    HLA B7 (HLA Class I B7 Alpha (HLA B7))
    Abstract
    HLA B7 Produkte
    Synonyme
    AS antikoerper, HLAB antikoerper, SPDA1 antikoerper, major histocompatibility complex, class I, B antikoerper, HLA-B antikoerper
    Hintergrund
    HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been describedSynonyms: B-7 alpha chain, HLA class I histocompatibility antigen, HLAB, MHC class I antigen B7
    Gen-ID
    3106
    NCBI Accession
    NP_005505
    UniProt
    P01889
    Pathways
    Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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