HLA-DMA Antikörper

Produktnummer ABIN1107564

Produktdetails anti-HLA-DMA Antikörper

Target: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser HLA-DMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: The antibody reacts with murine MHC class II glycoproteins. It recognizes a shared determinant on I-Ab, I-Ad, I-Aq, and I-Ed, I-Ek alloantigens, but it does not react with I-Af, I-Ak, I-As. This antibody can inhibit I-A-restricted T cell responses of the H-2b, H-2d, H-2q, H-2u but not H-2f, H-2k, H-2s haplotypes.

Kreuzreaktivität (Details): Species reactivity (tested):Mouse

Aufreinigung: Protein-G affinity chromatography

Reinheit: > 95 % pure by SDS-PAGE

Immunogen: Activated C57BL/6 mouse spleen cells

Klon: M5-114

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μm filter sterilized

Konservierungsmittel: Azide free

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Details zu HLA-DMA

Target: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Abstract: HLA-DMA Produkte

Hintergrund: MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long.Synonyms: DM alpha chain, DMA, HLA class II histocompatibility antigen, MHC class II antigen DMA, RING6, Really interesting new gene 6 protein

Gen-ID: 3108

NCBI Accession: NP_006111

UniProt: P28067

Pathways: Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response