HTRA2 Antikörper
(1 reference)-
- Target Alle HTRA2 Antikörper anzeigen
- HTRA2 (HtrA Serine Peptidase 2 (HTRA2))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser HTRA2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
- Spezifität
- This antibody reacts with HtrA2/Omi (40 kDa) on Western blotting.
- Aufreinigung
- Protein-A Agarose Chromatography of hybridoma supernatant.
- Immunogen
- Human recombinant 6His tagged HtrA2/Omi.
- Klon
- 18-01-83
- Isotyp
- IgG2a
- Top Product
- Discover our top product HTRA2 Primärantikörper
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anti-HtrA Serine Peptidase 2 (HTRA2) (AA 278-458) antibody
HTRA2 Reaktivität: Human WB, ELISA, IHC, FACS Wirt: Maus Monoclonal 6H7A8 unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) (AA 334-458) antibodyHTRA2 Reaktivität: Human WB, ELISA, IHC, IP Wirt: Kaninchen Polyclonal unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) (AA 359-458) antibodyHTRA2 Reaktivität: Human WB, ELISA, IF Wirt: Maus Monoclonal 4F10 unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) (AA 73-102), (N-Term) antibodyHTRA2 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB33645 unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) (AA 231-330) antibodyHTRA2 Reaktivität: Human, Maus, Ratte WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) antibodyHTRA2 Reaktivität: Human WB, IP Wirt: Maus Monoclonal 8G11-4B8-4F10-G5 unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) (AA 335-350) antibodyHTRA2 Reaktivität: Human WB, IHC Wirt: Maus Monoclonal 196C429 unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) antibodyHTRA2 Reaktivität: Human, Maus, Ratte WB, IHC, IF, IC Wirt: Kaninchen Polyclonal unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) antibodyHTRA2 Reaktivität: Human, Maus WB, ELISA Wirt: Maus Monoclonal 1B3 unconjugated
anti-HtrA Serine Peptidase 2 (HTRA2) (AA 134-458) antibodyHTRA2 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 1B3 unconjugated
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- PBS, pH 7.2 containing 50 % Glycerol without preservatives.
- Konservierungsmittel
- Without preservative
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store the antibody (in aliquots) at -20 °C.
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: "Neuroprotective function of Omi to α-synuclein-induced neurotoxicity." in: Neurobiology of disease, Vol. 136, pp. 104706, (2021) (PubMed).
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: "Neuroprotective function of Omi to α-synuclein-induced neurotoxicity." in: Neurobiology of disease, Vol. 136, pp. 104706, (2021) (PubMed).
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- Target
- HTRA2 (HtrA Serine Peptidase 2 (HTRA2))
- Andere Bezeichnung
- HTRA2 / PRSS25 (HTRA2 Produkte)
- Hintergrund
- HtrA2, also known as Omi or Serine Protease-25, is a trimeric chaperone/heat shock protein involved in the degradation of aberrantly folded proteins during cellular stress. The ubiquitous HtrA2 protein exists as two isoforms of 38 and 40 kDa and as an alternatively spliced form called D-Omi, which is predominately expressed in the kidney, colon and thyroid. HtrA2 appears to function in the progression of arthritis, aging, and tumor progression. During apoptosis, HtrA2 is released from mitochondria into the cytoplasm where it inhibits XIAP, a caspase inhibitor. Release of HtrA2 from mitochondria appears to require Bax and Bcl-2, and the resulting overexpression of HtrA2 into the cytoplasm induces caspase-independent apoptosis.Synonyms: High temperature requirement protein A2, OMI, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, mitochondrial Serine protease HTRA2
- Gen-ID
- 27429
- NCBI Accession
- NP_037379
- UniProt
- O43464
- Pathways
- Positive Regulation of Endopeptidase Activity
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