HTRA2 Antikörper

Produktnummer ABIN1107619

Produktdetails anti-HTRA2 Antikörper

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HTRA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Spezifität: This antibody reacts with HtrA2/Omi (40 kDa) on Western blotting.

Aufreinigung: Protein-A Agarose Chromatography of hybridoma supernatant.

Immunogen: Human recombinant 6His tagged HtrA2/Omi.

Klon: 18-01-83

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Referenzen für anti-HTRA2 Antikörper (ABIN1107619)

Chung, Islam, Rahman, Hong: "Neuroprotective function of Omi to α-synuclein-induced neurotoxicity." in: Neurobiology of disease, Vol. 136, pp. 104706, (2021) (PubMed).

Details zu HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Andere Bezeichnung: HTRA2 / PRSS25 (HTRA2 Produkte)

Synonyme: CG8464 antikoerper, DmHtrA2 antikoerper, Dmel\\CG8464 antikoerper, HtrA2/Omi antikoerper, Omi antikoerper, dOmi antikoerper, domi antikoerper, htrA2 antikoerper, omi antikoerper, HTRA2 antikoerper, PRSS25 antikoerper, OMI antikoerper, PARK13 antikoerper, AI481710 antikoerper, Prss25 antikoerper, mnd2 antikoerper, HTRA2-related serine protease antikoerper, HtrA serine peptidase 2 antikoerper, HtrA2 antikoerper, HTRA2 antikoerper, htra2 antikoerper, Htra2 antikoerper

Hintergrund: HtrA2, also known as Omi or Serine Protease-25, is a trimeric chaperone/heat shock protein involved in the degradation of aberrantly folded proteins during cellular stress. The ubiquitous HtrA2 protein exists as two isoforms of 38 and 40 kDa and as an alternatively spliced form called D-Omi, which is predominately expressed in the kidney, colon and thyroid. HtrA2 appears to function in the progression of arthritis, aging, and tumor progression. During apoptosis, HtrA2 is released from mitochondria into the cytoplasm where it inhibits XIAP, a caspase inhibitor. Release of HtrA2 from mitochondria appears to require Bax and Bcl-2, and the resulting overexpression of HtrA2 into the cytoplasm induces caspase-independent apoptosis.Synonyms: High temperature requirement protein A2, OMI, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, mitochondrial Serine protease HTRA2

Gen-ID: 27429

NCBI Accession: NP_037379

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity