Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
0.1 mg/mL
Buffer
PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store at 2 - 8 °C.
Shimazaki, Kamio, Nam, Harakawa, Tanaka, Omata, Saito, Kumura, Mikawa, Igarashi, Suzuki: "Structural and immunochemical studies on bovine lactoferrin fragments." in: Advances in experimental medicine and biology, Vol. 443, pp. 41-8, (1998) (PubMed).
Shimazaki, Nam, Harakawa, Tanaka, Omata, Saito, Kumura, Mikawa, Igarashi, Suzuki: "Monoclonal antibody against bovine Lactoferricin and its epitopic site." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Vol. 58, Issue 12, pp. 1227-9, (1997) (PubMed).
Lactoferricin B is derived by enzymatic cleavage of lactoferrin which is a member of the transferrin family of metal-binding proteins found in milk and other secretory fluids and also in blood. Cleavage by pepsin of bovine lactoferrin leads to the release of Lactoferricin B (aminoacid 17-41). This peptide is highly basic, possessing five Arg (R) and three Lys (K) residues. In addition, a number of Trp (W) and Phe (F) aromatic residues are present. The two Cys (C) residues from lactoferricin B form a disulfide bond, generating an almost completely cyclical peptide. Nevertheless, the disulfide bond is not required for the antimicrobial potency. Several studies have shown that Lactoferricin B has a broad-spectrum activity against various Gram-positive and Gram-negative bacteria. In addition the peptide has been shown to have antifungal, antiviral and antitumour activity and to bind lipopolysaccharides (LPS, endotoxin). Moreover, it is known to stimulate the adaptive immune response and has anti-inflammatory properties. Lactoferricin B belongs to a large group of cationic antimicrobial peptides.Synonyms: EC=3.4.21, LF, LTF, Lactoferrin, Talalactoferrin