MBP/MBL Antikörper

Produktnummer ABIN1108115

Produktdetails anti-MBP/MBL Antikörper

Target: MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser MBP/MBL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Immunofluorescence (IF)

Kreuzreaktivität (Details): Species reactivity (tested):Mouse

Aufreinigung: Protein G

Immunogen: Purified MBL-C

Klon: 14D12

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu MBP/MBL

Target: MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))

Andere Bezeichnung: Mannan Binding Protein (MBP/MBL Produkte)

Synonyme: COLEC1 antikoerper, HSMBPC antikoerper, MBL antikoerper, MBL2D antikoerper, MBP antikoerper, MBP-C antikoerper, MBP1 antikoerper, MBPD antikoerper, pMBP-27 antikoerper, MBL1 antikoerper, cMBl antikoerper, collectin antikoerper, L-MBP antikoerper, MBL-C antikoerper, RaRF p28A antikoerper, mbl antikoerper, mannose binding lectin 2 antikoerper, mannose-binding lectin (protein C) 2 antikoerper, mannose-binding protein C-like antikoerper, MBL2 antikoerper, Mbl2 antikoerper, LOC100911854 antikoerper

Hintergrund: Mannose binding lectin (MBL), also called mannose- or mannan-binding protein (MBP), is a member of the group of collectins. MBL is an important pattern-recognition receptor in the innate immune system. The protein mediates innate immune responses, such as activation of the complement lectin pathway and phagocytosis, to help fight infections. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. Binding of MBL leads to the activation of MBL-associated serine proteases (MASP's). Activated MASP-2 cleaves C4 and C2 in a similar way as C1s do for the classical pathway (CP) leading to the formation of C4b2a, cleavage of the classical pathway convertase C3, and eventually complement activation up to the formation of the membrane attack complex. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. MBL is predominantly synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Only one form of human MBL has been characterized, while two forms are found in rhesus monkeys, rabbits, rats and mice. The mouse forms are known as MBL-A and MBL-C. The MBL-C concentrations in serum are about 6-fold compared to that of MBL-A. MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS-injection models. MBL-C exists in higher oligomeric forms than MBL-A.Synonyms: MBL, MBL2, MBP, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, Mannose-binding protein C

Gen-ID: 17195

NCBI Accession: NP_034906

UniProt: P41317