cDNA Sequence AF251705 (AF251705) Antikörper

Produktnummer ABIN1108296

Produktdetails

Target: cDNA Sequence AF251705 (AF251705)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Flow Cytometry (FACS)

Spezifität: This antibody reacts with CD300d antigen.

Kreuzreaktivität (Details): Species reactivity (tested):Human (U937, Monocytes)

Aufreinigung: Protein A agarose

Immunogen: Ba/F3 transfectant expressing the human MAIR-II

Klon: TX45

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Antigendetails

Target: cDNA Sequence AF251705 (AF251705)

Andere Bezeichnung: MAIR-2 (Myeloid-Associated Immunoglobulin-Like Receptor) (AF251705 Produkte)

Synonyme: CLM4 antikoerper, Cd300c antikoerper, Cd300d antikoerper, DIgR1 antikoerper, Igsf7 antikoerper, Lmir2 antikoerper, MAIR-II antikoerper, CD300C molecule 2 antikoerper, Cd300c2 antikoerper

Hintergrund: Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Shibuya et al. identified novel paired activated and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domains. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12. MAIR-I is also known as CD300a/ CMRF-35-like Ig-like molecule-8 (CLM-8)/leukocyte mono-Ig-like receptor 1 (LMIR1). MAIR-II is also known as CD300d/LMIR2/CLM-4/dendritic cell-derived Ig-like receptor 1 (DIgR1).

Gen-ID: 140497

NCBI Accession: NP_598919

UniProt: Q7TSN2