The antibody recognizes Mouse Spi-6, also known as Serpin B9, a cytoplasmic serine protease inhibitor of ~42 kDa. It shows no crossreactivity with Mouse proteins related to Spi-6.
SERPINB9 antikoerper, BB283241 antikoerper, CAP-3 antikoerper, CAP3 antikoerper, PI-9 antikoerper, PI9 antikoerper, Spi6 antikoerper, ovalbumin antikoerper, serpin family B member 9 antikoerper, serpin peptidase inhibitor, clade B (ovalbumin), member 9 antikoerper, serine (or cysteine) peptidase inhibitor, clade B, member 9 antikoerper, Serpinb9 antikoerper, SERPINB9 antikoerper
Hintergrund
Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune-privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer.Synonyms: Cytoplasmic antiproteinase 3, PI-9, serpin B9