PRSS1
Reaktivität: Human
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
ELISA: May be used in immunoassays to detect and quantitate Pancreatic Trypsin. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
1.0 mg/mL (OD 280 nm)
Buffer
PBS, pH 7.4 without preservatives.
Konservierungsmittel
Without preservative
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
The human pancreas secretes three different isoforms of the inactive trypsinogen into the small intestine, namely cationic trypsinogen, anionic trypsinogen (the two major isoforms) and mesotrypsinogen (a minor isoform). In the small intestine, each isoform is cleaved by Enterokinase into its active form, Trypsin-1, Trypsin-2 and Trypsin-3, respectively. All trypsins are members of the serine protease trypsin family. The activated trypsins go on to activate other protease zymogens and play a role in the autoactivation of trypsinogens. This suggests an important role for trypsins in digestion. Mutations in the gene encoding Trypsin-1 that stimulate its activity are associated with autosomal dominant hereditary pancreatitis (HCP), also known as chronic pancreatitis (CP), a disease characterized by persistent, severe abdominal pain due to calcifications of the parenchyma, pancreatic stones, cysts and pancreatic head enlargement. Trypsin-3, also known as Trypsin-4, is expressed in the brain in addition to the pancreas.Synonyms: Beta-trypsin, Cationic trypsinogen, Serine protease 1, TRP1, TRY1, TRYP1, Trypsin I