PRKDC Antikörper (Catalytic Subunit)

Produktnummer ABIN1112714

Produktdetails anti-PRKDC Antikörper

Target: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Bindungsspezifität: Catalytic Subunit

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PRKDC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Immunogen: Recombinant DNA-PKcs protein.

Klon: N9

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB (1:1000), IHC-P (1:200), ICC (1:100). Other applications have not been tested. The optimal dilutions should be determined by end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu PRKDC

Target: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Abstract: PRKDC Produkte

Hintergrund: DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that belongs to the phosphatidylinositol 3-kinase-related kinase protein family. Anderson and Lees-Miller (1992) noted that DNA-PK had been shown in vitro to phosphorylate several transcription factors, suggesting that it functions in cell homeostasis by modulating transcription. It acts as a molecular sensor for DNA damage, and it may also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage.

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response