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ACTC1 Antikörper

ACTC1 Reaktivität: Human, Kaninchen, Huhn, Rind (Kuh) WB, IHC (p), IHC (fro), EIA Wirt: Maus Monoclonal AC1-20-4-2 unconjugated
Produktnummer ABIN112213
  • Target Alle ACTC1 Antikörper anzeigen
    ACTC1 (Actin, Alpha, Cardiac Muscle 1 (ACTC1))
    Reaktivität
    • 36
    • 26
    • 24
    • 9
    • 4
    • 4
    • 2
    • 2
    • 2
    Human, Kaninchen, Huhn, Rind (Kuh)
    Wirt
    • 22
    • 16
    Maus
    Klonalität
    • 20
    • 18
    Monoklonal
    Konjugat
    • 24
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser ACTC1 Antikörper ist unkonjugiert
    Applikation
    • 23
    • 12
    • 9
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody is specific for Fetal (Cardiac) isoform of Actin. Clone Ac1 represents an excellent marker for cardiac tissue. It discriminates fetal (cardiac) alpha-Actin from all other Actin isoforms. Mab Ac1-20.4.2 shows no cross reaction with other Actin isoforms present in skeletal and smooth muscle, provided that stringent conditions have been applied (see Special Treatment).
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Bovine, Rabbit and Chicken.
    Aufreinigung
    Affinity Chromatographyon Protein G.
    Immunogen
    Synthetic NH2 terminus decapeptide of cardiac isoform of Actin.
    Klon
    AC1-20-4-2
    Isotyp
    IgG1
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    Discover our top product ACTC1 Primärantikörper
  • Applikationshinweise
    ELISA: 1/500. Western Blot: 1/1000 (using the ECL-enhanced procedure). Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin-Embedded Tissue: 1/10 (After microwave treatment). Incubation time: 1 h at RT. Special Treatment: It is necessary to include 0.5 M NaCl in all washing buffers forapplication on Frozen tissue and 1 M NaCl for Western blotting and ELISA to enhancespecifity. This is not necessary for Paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    Restore in 1.0 mL distilled water.
    Buffer
    Final Solution contains PBS, pH 7.4 with 0.09 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Dilute only prior to immediate use. Avoid cycles of freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Skwarek-Maruszewska, Hotulainen, Mattila, Lappalainen: "Contractility-dependent actin dynamics in cardiomyocyte sarcomeres." in: Journal of cell science, Vol. 122, Issue Pt 12, pp. 2119-26, (2009) (PubMed).

    Itzhaki-Alfia, Leor, Raanani, Sternik, Spiegelstein, Netser, Holbova, Pevsner-Fischer, Lavee, Barbash: "Patient characteristics and cell source determine the number of isolated human cardiac progenitor cells." in: Circulation, Vol. 120, Issue 25, pp. 2559-66, (2009) (PubMed).

    Lechler, Wu, Bernhardt, Campean, Gastiger, Hackenbeck, Klanke, Weidemann, Warnecke, Amann, Engehausen, Willam, Eckardt, Rödel, Wiesener: "The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney." in: The American journal of pathology, Vol. 171, Issue 5, pp. 1483-98, (2007) (PubMed).

  • Target
    ACTC1 (Actin, Alpha, Cardiac Muscle 1 (ACTC1))
    Abstract
    ACTC1 Produkte
    Synonyme
    acta1 antikoerper, actc antikoerper, fa27h01 antikoerper, fb83f06 antikoerper, wu:fa27h01 antikoerper, wu:fb83f06 antikoerper, ACTC antikoerper, ASD5 antikoerper, CMD1R antikoerper, CMH11 antikoerper, LVNC4 antikoerper, Actc-1 antikoerper, actcl antikoerper, actc1l antikoerper, cmd1r antikoerper, ACTC1 antikoerper, actin, alpha, cardiac muscle 1 L homeolog antikoerper, actin, alpha, cardiac muscle 1b antikoerper, actin, alpha, cardiac muscle 1 antikoerper, actin, alpha, cardiac muscle 1a antikoerper, actc1.L antikoerper, actc1b antikoerper, ACTC1 antikoerper, Actc1 antikoerper, actc1a antikoerper, actc1 antikoerper
    Hintergrund
    Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. ACTB/ACTC are nonmuscle cytoskeletal actins and major constituents of the contractile apparatus. Defects in ACTB are a cause of juvenile-onset dystonia. Defects in ACTC have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). Fetal Actin can be localized in regenerating skeletal muscle after injury (in satellite cells) and in veins of the umbelical cord.
    Gen-ID
    70
    NCBI Accession
    NP_005150
    UniProt
    P68032
    Pathways
    Myometrial Relaxation and Contraction
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