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ITM2B Antikörper

ITM2B Reaktivität: Human IHC (fro) Wirt: Huhn Polyclonal unconjugated
Produktnummer ABIN113338
  • Target Alle ITM2B Antikörper anzeigen
    ITM2B (Integral Membrane Protein 2B (ITM2B))
    Reaktivität
    • 27
    • 12
    • 2
    • 1
    Human
    Wirt
    • 28
    • 4
    • 1
    • 1
    • 1
    Huhn
    Klonalität
    • 33
    • 2
    Polyklonal
    Konjugat
    • 19
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ITM2B Antikörper ist unkonjugiert
    Applikation
    • 23
    • 17
    • 16
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunohistochemistry (Frozen Sections) (IHC (fro))
    Sequenz
    CSRTVKKNII EEN
    Spezifität
    The antibody recognizes the typical amyloid deposits in brains of patients suffering from the disease. This antibody has been developed against the carboxy terminal extracellular sequence of the mutated BRI protein.
    Aufreinigung
    Affinity chromatography.
    Immunogen
    Peptide coupled to carrier protein.
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    Discover our top product ITM2B Primärantikörper
  • Applikationshinweise
    Suitable for Immunohistochemistry on frozen sections. Suggested positive control: pathological brain sections. (Not recommended in Western blots).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg /ml
    Buffer
    PBS, pH 7.2, containing 0.09 % sodium azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody at 2-8 °C (Lyophilized) or reconstituted in small aliquots at -20 °C.
  • Target
    ITM2B (Integral Membrane Protein 2B (ITM2B))
    Andere Bezeichnung
    ITM2B (ITM2B Produkte)
    Hintergrund
    The mutated BRI protein (ITM2B) was identified in patients with familial British dementia. The unusual 277 residue precursor protein releases a 34-residue amyloidogenic peptide by the action of the protease furin, leading to the deposition of a protein fragment that seems to be involved in the pathogenesis of familial British dementia.Synonyms: BRI, BRI2, ITM2B, Integral membrane protein 2B, Transmembrane protein BRI
    Gen-ID
    9445
    NCBI Accession
    NP_068839
    UniProt
    Q9Y287
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