CXCL12 Antikörper
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- Target Alle CXCL12 Antikörper anzeigen
- CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CXCL12 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Functional Studies (Func)
- Spezifität
- This antibody detects Human Stromal Cell Derived Factor-1 alpha. Other species not tested.
- Aufreinigung
- Affinity Chromatography employing immobilized Human SDF1a matrix.
- Immunogen
- Highly pure (>98%) E.coli derived recombinant Human SDF1-alpha.
- Top Product
- Discover our top product CXCL12 Primärantikörper
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- Applikationshinweise
- Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of hSDF1α (100 ng/mL),a concentration of 2-4 μg/mL of this antibody is required. ELISA: Indirect: Using 100 μL/well antibody solution, a concentration of 0.5-2.0 μg/mL is required. In conjunction with compatible secondary reagents, it allows the detection of at least 0.2 -0.4 ng/well of recombinant hSDF-1α. Sandwich: Using 100 μL/well antibody solution, a concentration of 0.5 - 2.0 μg/mL isrequired. In conjunction with Biotinylated Anti-Human SDF-1α (PP1067B) as a detectionantibody, it allows the detection of at least 0.2-0.4 ng/well of recombinant hSDF-1α. Western Blot: 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limitfor recombinant hSDF-1α is 1.5-3.0 ng/lane, under either reducing or non-reducingconditions.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Rekonstitution
- Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
- Buffer
- PBS, pH 7.2 without preservatives.
- Konservierungsmittel
- Without preservative
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should protected from light.
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TLR7/8 triggering exerts opposing effects in acute versus latent HIV infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 5, pp. 2888-95, (2006) (PubMed).
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TLR7/8 triggering exerts opposing effects in acute versus latent HIV infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 5, pp. 2888-95, (2006) (PubMed).
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- Target
- CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))
- Andere Bezeichnung
- CXCL12 / SDF1 (CXCL12 Produkte)
- Synonyme
- IRH antikoerper, PBSF antikoerper, SCYB12 antikoerper, SDF1 antikoerper, TLSF antikoerper, TPAR1 antikoerper, CINC-1 antikoerper, Gro1 antikoerper, Pbsf antikoerper, Scyb12 antikoerper, Sdf1 antikoerper, Tlsf antikoerper, Tpar1 antikoerper, Fsp antikoerper, KC antikoerper, Mgsa antikoerper, N51 antikoerper, Scyb1 antikoerper, gro antikoerper, sdf-1 antikoerper, sdf1 antikoerper, xSDF-1 antikoerper, SDF-1 antikoerper, cxcl12 antikoerper, sdf-1a antikoerper, sdf1a antikoerper, wu:fa55e10 antikoerper, wu:fc16h12 antikoerper, wu:fj84c02 antikoerper, C-X-C motif chemokine ligand 12 antikoerper, C-X-C motif chemokine ligand 1 antikoerper, chemokine (C-X-C motif) ligand 12 antikoerper, chemokine (C-X-C motif) ligand 1 antikoerper, C-X-C motif chemokine ligand 12 L homeolog antikoerper, chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) antikoerper, CXCL12 antikoerper, cxcl12 antikoerper, Cxcl1 antikoerper, Cxcl12 antikoerper, cxcl12.L antikoerper, cxcl12a antikoerper
- Hintergrund
- SDF1 alpha and 1 beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF or IL1. SDF1 alpha has been shown to be chemotactic for lymphocytes and is recently reported to be a ligand for CXCR4 (LESTR/fusin), a co-receptor for HIV1 entry into T cells. SDF-1 binding to CXCR4 inhibits HIV1 entry.Synonyms: C-X-C motif chemokine 12, IRH, Intercrine reduced in hepatomas, PBSF, Pre-B cell growth-stimulating factor, SDF1A, SDF1B, Stromal cell-derived factor 1, hIRH
- Gen-ID
- 6387
- NCBI Accession
- NP_000600
- UniProt
- P48061
- Pathways
- Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling
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