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FLIP Antikörper (AA 1-480)

CFLAR Reaktivität: Human, Maus WB, IP Wirt: Ratte Monoclonal Dave-2 unconjugated
Produktnummer ABIN1169019
  • Target Alle FLIP (CFLAR) Antikörper anzeigen
    FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
    Bindungsspezifität
    • 16
    • 15
    • 15
    • 8
    • 7
    • 7
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-480
    Reaktivität
    • 100
    • 66
    • 58
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 91
    • 14
    • 1
    Ratte
    Klonalität
    • 93
    • 13
    Monoklonal
    Konjugat
    • 52
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FLIP Antikörper ist unkonjugiert
    Applikation
    • 95
    • 39
    • 26
    • 26
    • 20
    • 19
    • 13
    • 12
    • 12
    • 10
    • 8
    • 5
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Spezifität
    Recognizes an epitope (aa 1-200) present in both short (FLIPS) and long (FLIPL) splice variants of human and mouse FLIP.
    Kreuzreaktivität
    Human, Maus
    Immunogen
    Recombinant human FLIP (aa 1-480).
    Klon
    Dave-2
    Isotyp
    IgG2a
    Top Product
    Discover our top product CFLAR Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Haltbarkeit
    12 months
  • Van Opdenbosch, Van Gorp, Verdonckt, Saavedra, de Vasconcelos, Gonçalves, Vande Walle, Demon, Matusiak, Van Hauwermeiren, DHont, Hochepied, Krautwald, Kanneganti, Lamkanfi: "Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4." in: Cell reports, Vol. 21, Issue 12, pp. 3427-3444, (2018) (PubMed).

    Dannappel, Vlantis, Kumari, Polykratis, Kim, Wachsmuth, Eftychi, Lin, Corona, Hermance, Zelic, Kirsch, Basic, Bleich, Kelliher, Pasparakis: "RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis." in: Nature, Vol. 513, Issue 7516, pp. 90-4, (2014) (PubMed).

    Lens, Kataoka, Fortner, Tinel, Ferrero, MacDonald, Hahne, Beermann, Attinger, Orbea, Budd, Tschopp: "The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes." in: Molecular and cellular biology, Vol. 22, Issue 15, pp. 5419-33, (2002) (PubMed).

    Gómez-Angelats, Cidlowski: "Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis." in: The Journal of biological chemistry, Vol. 276, Issue 48, pp. 44944-52, (2001) (PubMed).

    Micheau, Lens, Gaide, Alevizopoulos, Tschopp: "NF-kappaB signals induce the expression of c-FLIP." in: Molecular and cellular biology, Vol. 21, Issue 16, pp. 5299-305, (2001) (PubMed).

    Djerbi, Darreh-Shori, Zhivotovsky, Grandien: "Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different flip isoforms." in: Scandinavian journal of immunology, Vol. 54, Issue 1-2, pp. 180-9, (2001) (PubMed).

    Rescigno, Piguet, Valzasina, Lens, Zubler, French, Kindler, Tschopp, Ricciardi-Castagnoli et al.: "Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate ..." in: The Journal of experimental medicine, Vol. 192, Issue 11, pp. 1661-8, (2000) (PubMed).

  • Target
    FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
    Andere Bezeichnung
    FLIP (CFLAR Produkte)
    Synonyme
    Clarp1 antikoerper, cflar antikoerper, CFLAR antikoerper, FLIP antikoerper, CASH antikoerper, CASP8AP1 antikoerper, CLARP antikoerper, Casper antikoerper, FLAME antikoerper, FLAME-1 antikoerper, FLAME1 antikoerper, I-FLICE antikoerper, MRIT antikoerper, c-FLIP antikoerper, c-FLIPL antikoerper, c-FLIPR antikoerper, c-FLIPS antikoerper, 2310024N18Rik antikoerper, A430105C05Rik antikoerper, Cash antikoerper, ENSMUSG00000072980 antikoerper, Flip antikoerper, Gm9845 antikoerper, c-Flip antikoerper, CASP8 and FADD-like apoptosis regulator a antikoerper, CASP8 and FADD like apoptosis regulator antikoerper, CASP8 and FADD like apoptosis regulator S homeolog antikoerper, CASP8 and FADD-like apoptosis regulator antikoerper, cflara antikoerper, CFLAR antikoerper, cflar antikoerper, cflar.S antikoerper, Cflar antikoerper
    Hintergrund
    FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.
    UniProt
    O15519
    Pathways
    Apoptose, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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