STS Antikörper (N-Term)

Produktnummer ABIN1169071

Produktdetails anti-STS Antikörper

Target: STS (Steroid Sulfatase (STS))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Functional Studies (Func)

Spezifität: Recognizes human and mouse Asc.

Kreuzreaktivität: Human, Maus

Immunogen: Synthetic peptide corresponding to aa at the N-terminal human Asc.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-STS Antikörper (ABIN1169071)

Cao, Tian, Li, Lv, Han, Zhuang, Cheng, Gong, Ying, Jin, Gao: "Suppression of NLRP3 Inflammasome by Erythropoietin via the EPOR/JAK2/STAT3 Pathway Contributes to Attenuation of Acute Lung Injury in Mice." in: Frontiers in pharmacology, Vol. 11, pp. 306, (2020) (PubMed).

Chen, Jiang, Liu, Li, Pei, Wang, Pan, Cui, Long, Wang, Zheng: "Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop." in: Bone research, Vol. 8, pp. 10, (2020) (PubMed).

Liu, Lu, Chen, Muthuraj, Li, Pattabiraman, Zempleni, Kachman, Natarajan, Yu: "Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice." in: Nutrients, Vol. 12, Issue 2, (2020) (PubMed).

Rudloff, Ung, Dowling, Mansell, DAndrea, Ellisdon, Whisstock, Berger, Nold-Petry, Nold: "Parsing the IL-37-Mediated Suppression of Inflammasome Function." in: Cells, Vol. 9, Issue 1, (2020) (PubMed).

Deng, Guo, Tam, Johnson, Brickey, New, Lenox, Shi, Golenbock, Koller, McKinnon, Beutler, Ting: "Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR." in: The Journal of experimental medicine, Vol. 216, Issue 12, pp. 2838-2853, (2020) (PubMed).

Sanchez-Lopez, Zhong, Stubelius, Sweeney, Booshehri, Antonucci, Liu-Bryan, Lodi, Terkeltaub, Lacal, Murphy, Hoffman, Tiziani, Guma, Karin: "Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production." in: Cell metabolism, Vol. 29, Issue 6, pp. 1350-1362.e7, (2020) (PubMed).

Guo, Liu, Jian, Cui, Fang, Zuo, Deng, Li, Wang, Zhao, Geng, Ouyang, Lai, Chen, Huang: "Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages." in: Aging, Vol. 11, Issue 23, pp. 11659-11672, (2019) (PubMed).

Martínez-García, Martínez-Banaclocha, Angosto-Bazarra, de Torre-Minguela, Baroja-Mazo, Alarcón-Vila, Martínez-Alarcón, Amores-Iniesta, Martín-Sánchez, Ercole, Martínez, González-Lisorge et al.: "P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis. ..." in: Nature communications, Vol. 10, Issue 1, pp. 2711, (2019) (PubMed).

Panaitescu, Romero, Gomez-Lopez, Xu, Leng, Maymon, Pacora, Erez, Yeo, Hassan, Hsu: "In vivo evidence of inflammasome activation during spontaneous labor at term." in: The journal of maternal-fetal & neonatal medicine, Vol. 32, Issue 12, pp. 1978-1991, (2019) (PubMed).

Wang, Gong, Zhang, Li, Lu, Zhao, Yu, Wei, Yang, Liu, Yang, Li, Zhang: "NLRP3 Inflammasome Participates in Host Response to Neospora caninum Infection." in: Frontiers in immunology, Vol. 9, pp. 1791, (2019) (PubMed).

Zhong, Liang, Sanchez-Lopez, He, Shalapour, Lin, Wong, Ding, Seki, Schnabl, Hevener, Greenberg, Kisseleva, Karin: "New mitochondrial DNA synthesis enables NLRP3 inflammasome activation." in: Nature, Vol. 560, Issue 7717, pp. 198-203, (2019) (PubMed).

Gomez-Lopez, Romero, Xu, Garcia-Flores, Leng, Panaitescu, Miller, Abrahams, Hassan: "Inflammasome assembly in the chorioamniotic membranes during spontaneous labor at term." in: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 77, Issue 5, (2018) (PubMed).

Gomez-Lopez, Romero, Panaitescu, Leng, Xu, Tarca, Faro, Pacora, Hassan, Hsu: "Inflammasome activation during spontaneous preterm labor with intra-amniotic infection or sterile intra-amniotic inflammation." in: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 80, Issue 5, pp. e13049, (2018) (PubMed).

Lugrin, Martinon: "Detection of ASC Oligomerization by Western Blotting." in: Bio-protocol, Vol. 7, Issue 10, (2017) (PubMed).

Dang, McDonald, Russell, Cyster: "Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation." in: Cell, Vol. 171, Issue 5, pp. 1057-1071.e11, (2017) (PubMed).

Fernández-Gil, Moneim, Ortiz, Shen, Soto-Mercado, Mendivil-Perez, Guerra-Librero, Acuña-Castroviejo, Molina-Navarro, García-Verdugo, Sayed, Florido, Luna, López, Escames: "Melatonin protects rats from radiotherapy-induced small intestine toxicity." in: PLoS ONE, Vol. 12, Issue 4, pp. e0174474, (2017) (PubMed).

Man, Karki, Sasai, Place, Kesavardhana, Temirov, Frase, Zhu, Malireddi, Kuriakose, Peters, Neale, Brown, Yamamoto, Kanneganti: "IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes." in: Cell, Vol. 167, Issue 2, pp. 382-396.e17, (2017) (PubMed).

Tervaniemi, Katayama, Skoog, Siitonen, Vuola, Nuutila, Sormunen, Johnsson, Linnarsson, Suomela, Kankuri, Kere, Elomaa: "NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis." in: Scientific reports, Vol. 6, pp. 22745, (2016) (PubMed).

Man, Karki, Malireddi, Neale, Vogel, Yamamoto, Lamkanfi, Kanneganti: "The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection." in: Nature immunology, Vol. 16, Issue 5, pp. 467-75, (2015) (PubMed).

Ortiz, Acuña-Castroviejo, Doerrier, Dayoub, López, Venegas, García, López, Volt, Luna-Sánchez, Escames: "Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis." in: Journal of pineal research, (2014) (PubMed).

Details zu STS

Target: STS (Steroid Sulfatase (STS))

Andere Bezeichnung: Asc (STS Produkte)

Synonyme: 9130417A21Rik antikoerper, Asc antikoerper, CARD5 antikoerper, TMS-1 antikoerper, TNS1 antikoerper, masc antikoerper, ARSC antikoerper, ARSC1 antikoerper, ASC antikoerper, ES antikoerper, SSDD antikoerper, XLI antikoerper, PYD and CARD domain containing antikoerper, steroid sulfatase antikoerper, Pycard antikoerper, STS antikoerper, Sts antikoerper

Hintergrund: Asc promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. It is a component of the inflammasome, a protein complex which also includes NLRP3/NALP3, CARD8 and CASP1 and whose function is the activation of proinflammatory caspases.

UniProt: Q9ULZ3

Pathways: Steroid Hormone Biosynthesis, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation