PIDD Antikörper (AA 776-910)

Produktnummer ABIN1169268

Produktdetails anti-PIDD Antikörper

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Bindungsspezifität: AA 776-910

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIDD Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP)

Spezifität: Recognizes human and the native form of mouse PIDD. Detects bands of ~90 kDa (full length protein) and ~50 kDa (cleaved protein) by Western blot.

Kreuzreaktivität: Human, Maus

Immunogen: Recombinant human PIDD (Death Domain: aa 776-910).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-PIDD Antikörper (ABIN1169268)

Milleron, Bratton: "Heat shock induces apoptosis independently of any known initiator caspase-activating complex." in: The Journal of biological chemistry, Vol. 281, Issue 25, pp. 16991-7000, (2006) (PubMed).

Janssens, Tinel, Lippens, Tschopp: "PIDD mediates NF-kappaB activation in response to DNA damage." in: Cell, Vol. 123, Issue 6, pp. 1079-92, (2005) (PubMed).

Tinel, Tschopp: "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress." in: Science (New York, N.Y.), Vol. 304, Issue 5672, pp. 843-6, (2004) (PubMed).

Details zu PIDD

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Andere Bezeichnung: PIDD (PIDD Produkte)

Synonyme: 1200011D09Rik antikoerper, AU042446 antikoerper, Pidd antikoerper, LRDD antikoerper, Lrdd antikoerper, p53 induced death domain protein 1 antikoerper, p53-induced death domain protein 1 antikoerper, Pidd1 antikoerper, PIDD1 antikoerper

Hintergrund: PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

UniProt: Q9HB75

Pathways: p53 Signalweg, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity