Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Caspase 1 p20 Antikörper

Reaktivität: Human WB Wirt: Maus Monoclonal Bally-1 unconjugated
Produktnummer ABIN1169380
  • Target Alle Caspase 1 p20 Produkte
    Caspase 1 p20
    Reaktivität
    • 50
    • 34
    • 32
    Human
    Wirt
    • 49
    • 3
    Maus
    Klonalität
    • 49
    • 3
    Monoklonal
    Konjugat
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Dieser Caspase 1 p20 Antikörper ist unkonjugiert
    Applikation
    • 42
    • 36
    • 26
    • 26
    • 10
    • 9
    • 6
    • 2
    • 2
    • 2
    Western Blotting (WB)
    Spezifität
    Recognizes endogenous full-length and activated (p20 fragment) human caspase-1.
    Kreuzreaktivität
    Human
    Aufreinigung
    Purified from concentrated hybridoma tissue culture supernatant.
    Reinheit
    >95 % (SDS-PAGE)
    Immunogen
    Recombinant human caspase-1.
    Klon
    Bally-1
    Isotyp
    IgG1
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Haltbarkeit
    12 months
  • Rolfes, Ribeiro, Hawwari, Böttcher, Rosero, Maasewerd, Santos, Próchnicki, Silva, Wanderley, Rothe, Schmidt, Stunden, Bertheloot, Rivas, Fontes, Carvalho, Cunha, Latz, Arditi, Franklin: "Platelets Fuel the Inflammasome Activation of Innate Immune Cells." in: Cell reports, Vol. 31, Issue 6, pp. 107615, (2020) (PubMed).

    Hamarsheh, Osswald, Saller, Unger, De Feo, Vinnakota, Konantz, Uhl, Becker, Lübbert, Shoumariyeh, Schürch, Andrieux, Venhoff, Schmitt-Graeff, Duquesne, Pfeifer, Cooper, Lengerke, Boerries, Duyster et al.: "Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. ..." in: Nature communications, Vol. 11, Issue 1, pp. 1659, (2020) (PubMed).

    Xue, Xi, Liu, Guo, Zhang, Zhang, Li, Yang, Zhou, Yang, Zhang, Zhang, Gu, Yang, Da, Yao, Duo, Zhang: "miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock." in: Cell death & disease, Vol. 10, Issue 6, pp. 461, (2020) (PubMed).

    Wu, Lu, Zhang, Zhang, Shi, Hisada, Grover, Zhang, Li, Xiang, Shi, Li, Daugherty, Smyth, Kirchhofer, Shiroishi, Shao, Mackman, Wei, Li: "Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis." in: Immunity, Vol. 50, Issue 6, pp. 1401-1411.e4, (2019) (PubMed).

    Mehto, Jena, Nath, Chauhan, Kolapalli, Das, Sahoo, Jain, Taylor, Chauhan: "The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy." in: Molecular cell, Vol. 73, Issue 3, pp. 429-445.e7, (2019) (PubMed).

    Honda, Sadatomi, Yamamura, Nakashioya, Tanimura, Takeda: "WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3." in: Cancer science, Vol. 108, Issue 3, pp. 520-527, (2017) (PubMed).

    Gaidt, Ebert, Chauhan, Ramshorn, Pinci, Zuber, ODuill, Schmid-Burgk, Hoss, Buhmann, Wittmann, Latz, Subklewe, Hornung: "The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3." in: Cell, Vol. 171, Issue 5, pp. 1110-1124.e18, (2017) (PubMed).

    Derangère, Chevriaux, Courtaut, Bruchard, Berger, Chalmin, Causse, Limagne, Végran, Ladoire, Simon, Boireau, Hichami, Apetoh, Mignot, Ghiringhelli, Rébé: "Liver X receptor ? activation induces pyroptosis of human and murine colon cancer cells." in: Cell death and differentiation, Vol. 21, Issue 12, pp. 1914-24, (2014) (PubMed).

  • Target
    Caspase 1 p20
    Andere Bezeichnung
    Caspase-1 p20 (Caspase 1 p20 Produkte)
    Hintergrund
    Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
    UniProt
    P29466
Sie sind hier:
Kundenservice