Caspase 1 p20 Antikörper

Produktnummer ABIN1169381

Produktdetails anti-Caspase 1 p20 Antikörper

Target: Caspase 1 p20

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Caspase 1 p20 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

Spezifität: Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1.

Kreuzreaktivität: Maus

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant mouse caspase-1.

Klon: Casper-1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-Caspase 1 p20 Antikörper (ABIN1169381)

Yamazaki, Ohshio, Sugamata, Morita: "Lactic acid bacterium, Lactobacillus paracasei KW3110, suppresses inflammatory stress-induced caspase-1 activation by promoting interleukin-10 production in mouse and human immune cells." in: PLoS ONE, Vol. 15, Issue 8, pp. e0237754, (2020) (PubMed).

Hooftman, Angiari, Hester, Corcoran, Runtsch, Ling, Ruzek, Slivka, McGettrick, Banahan, Hughes, Irvine, Fischer, ONeill: "The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation." in: Cell metabolism, Vol. 32, Issue 3, pp. 468-478.e7, (2020) (PubMed).

de Vasconcelos, Van Opdenbosch, Van Gorp, Martín-Pérez, Zecchin, Vandenabeele, Lamkanfi: "An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages." in: Cell reports, Vol. 32, Issue 4, pp. 107959, (2020) (PubMed).

Heilig, Dilucca, Boucher, Chen, Hancz, Demarco, Shkarina, Broz: "Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD." in: Life science alliance, Vol. 3, Issue 6, (2020) (PubMed).

Wang, Li, Liu, Peng, Zhu, Tu, Yu, Li: "CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis." in: Frontiers in medicine, Vol. 7, pp. 88, (2020) (PubMed).

Donado, Cao, Simmons, Croker, Brennan, Brenner: "A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling." in: Cell reports, Vol. 31, Issue 1, pp. 107466, (2020) (PubMed).

Place, Briard, Samir, Karki, Bhattacharya, Guy, Peters, Frase, Vogel, Neale, Yamamoto, Kanneganti: "Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion." in: PLoS pathogens, Vol. 16, Issue 3, pp. e1008364, (2020) (PubMed).

Subbarao, Sanchez-Garrido, Krishnan, Shenoy, Robertson: "Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages." in: Scientific reports, Vol. 10, Issue 1, pp. 3709, (2020) (PubMed).

Cohen, Baram, Edry-Botzer, Munitz, Salomon, Gerlic: "Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome." in: Emerging microbes & infections, Vol. 9, Issue 1, pp. 278-290, (2020) (PubMed).

Wang, Xu, Zhao, Yin, Liu, Chen, Hou: "Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice." in: Nature communications, Vol. 11, Issue 1, pp. 220, (2020) (PubMed).

Krause, Daily, Estfanous, Hamilton, Badr, Abu Khweek, Hegazi, Anne, Klamer, Zhang, Gavrilin, Pancholi, Amer: "Caspase-11 counteracts mitochondrial ROS-mediated clearance of Staphylococcus aureus in macrophages." in: EMBO reports, Vol. 20, Issue 12, pp. e48109, (2020) (PubMed).

de Vasconcelos, Vliegen, Gonçalves, De Hert, Martín-Pérez, Van Opdenbosch, Jallapally, Geiss-Friedlander, Lambeir, Augustyns, Van Der Veken, De Meester, Lamkanfi: "DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages." in: Life science alliance, Vol. 2, Issue 1, (2020) (PubMed).

Hamarsheh, Osswald, Saller, Unger, De Feo, Vinnakota, Konantz, Uhl, Becker, Lübbert, Shoumariyeh, Schürch, Andrieux, Venhoff, Schmitt-Graeff, Duquesne, Pfeifer, Cooper, Lengerke, Boerries, Duyster et al.: "Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. ..." in: Nature communications, Vol. 11, Issue 1, pp. 1659, (2020) (PubMed).

Wooff, Fernando, Wong, Dietrich, Aggio-Bruce, Chu-Tan, Robertson, Doyle, Man, Natoli: "Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration." in: Scientific reports, Vol. 10, Issue 1, pp. 2263, (2020) (PubMed).

Cai, Ge, Mennone, Hoque, Ouyang, Boyer: "Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct-Ligated Mouse." in: Cellular and molecular gastroenterology and hepatology, Vol. 9, Issue 4, pp. 679-688, (2020) (PubMed).

Deng, Guo, Tam, Johnson, Brickey, New, Lenox, Shi, Golenbock, Koller, McKinnon, Beutler, Ting: "Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR." in: The Journal of experimental medicine, Vol. 216, Issue 12, pp. 2838-2853, (2020) (PubMed).

Sharif, Wang, Wang, Magupalli, Andreeva, Qiao, Hauenstein, Wu, Núñez, Mao, Wu: "Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome." in: Nature, Vol. 570, Issue 7761, pp. 338-343, (2020) (PubMed).

Xue, Xi, Liu, Guo, Zhang, Zhang, Li, Yang, Zhou, Yang, Zhang, Zhang, Gu, Yang, Da, Yao, Duo, Zhang: "miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock." in: Cell death & disease, Vol. 10, Issue 6, pp. 461, (2020) (PubMed).

Sanchez-Lopez, Zhong, Stubelius, Sweeney, Booshehri, Antonucci, Liu-Bryan, Lodi, Terkeltaub, Lacal, Murphy, Hoffman, Tiziani, Guma, Karin: "Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production." in: Cell metabolism, Vol. 29, Issue 6, pp. 1350-1362.e7, (2020) (PubMed).

Mamantopoulos, Frising, Asaoka, van Loo, Lamkanfi, Wullaert: "El Tor Biotype Vibrio cholerae Activates the Caspase-11-Independent Canonical Nlrp3 and Pyrin Inflammasomes." in: Frontiers in immunology, Vol. 10, pp. 2463, (2019) (PubMed).

Details zu Caspase 1 p20

Target: Caspase 1 p20

Andere Bezeichnung: Caspase-1 p20 (Caspase 1 p20 Produkte)

Hintergrund: Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.

UniProt: P29452