Caspase 1 (p10) Antikörper

Produktnummer ABIN1169386

Produktdetails anti-Caspase 1 (p10) Antikörper

Target: Caspase 1 (p10) (CASP-1 (p10))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Caspase 1 (p10) Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Recognizes endogenous full-length and activated (p10 fragment) mouse caspase-1.

Kreuzreaktivität: Maus

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant mouse caspase-1.

Klon: Casper-2

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-Caspase 1 (p10) Antikörper (ABIN1169386)

Chevriaux, Pilot, Derangère, Simonin, Martine, Chalmin, Ghiringhelli, Rébé: "Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction." in: Frontiers in cell and developmental biology, Vol. 8, pp. 167, (2020) (PubMed).

Liu, Lu, Chen, Muthuraj, Li, Pattabiraman, Zempleni, Kachman, Natarajan, Yu: "Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice." in: Nutrients, Vol. 12, Issue 2, (2020) (PubMed).

Deng, Guo, Tam, Johnson, Brickey, New, Lenox, Shi, Golenbock, Koller, McKinnon, Beutler, Ting: "Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR." in: The Journal of experimental medicine, Vol. 216, Issue 12, pp. 2838-2853, (2020) (PubMed).

Wong, Li, Rao, Yang, Cheng, Lin, Cheng, Chen, Hua: "Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome." in: Frontiers in immunology, Vol. 9, pp. 1920, (2018) (PubMed).

Freeman, Guo, David, Brickey, Jha, Ting: "NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes." in: The Journal of experimental medicine, Vol. 214, Issue 5, pp. 1351-1370, (2017) (PubMed).

Yabal, Müller, Adler, Knies, Groß, Damgaard, Kanegane, Ringelhan, Kaufmann, Heikenwälder, Strasser, Groß, Ruland, Peschel, Gyrd-Hansen, Jost: "XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation." in: Cell reports, Vol. 7, Issue 6, pp. 1796-808, (2014) (PubMed).

Details zu Caspase 1 (p10)

Target: Caspase 1 (p10) (CASP-1 (p10))

Andere Bezeichnung: Caspase-1 p10 (CASP-1 (p10) Produkte)

Hintergrund: Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.

UniProt: P29452