Cullin 7 Antikörper (C-Term)
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- Target Alle Cullin 7 (CUL7) Antikörper anzeigen
- Cullin 7 (CUL7)
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Bindungsspezifität
- AA 1679-1698, C-Term
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Cullin 7 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Spezifität
- This product is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. This product reacts with human and mouse Cullin 7. Cross reactivity with other human cullins may occur.
- Aufreinigung
- Delipidation and defibrination.
- Immunogen
- Synthetic peptide corresponding to amino acids 1679-1698 of Human Cul7 (C-terminus) coupled coupled to KLH.
- Top Product
- Discover our top product CUL7 Primärantikörper
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- Applikationshinweise
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Western blot (1/500-1/1,000): This antibody reacts with human Cul7, An 191.2 kDa bandcorresponding to human Cul7 is detected, Most cell lines expressing Cul7 can be used as apositive control. Immunoprecipitation: The antibody immunoprecipitates in vitro translated protein andalso protein from cell lysates (using HeLa or NIH-3T3 and others. This antibody alsoco-immunoprecipitates associated proteins in overexpressed CUL7 systems). ELISA: 1/2,000-1/10,000 Dilution.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 85.0 mg/mL (by Refractometry)
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store undiluted at 2-8 °C.
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- Target
- Cullin 7 (CUL7)
- Andere Bezeichnung
- Cullin-7 (CUL7 Produkte)
- Synonyme
- cullin-7 antikoerper, CUL7 antikoerper, Cullin-7 antikoerper, KIAA0076 antikoerper, dJ20C7.5 antikoerper, 2510004L20Rik antikoerper, AA409809 antikoerper, C230011P08Rik antikoerper, p185 antikoerper, p193 antikoerper, cullin 7 antikoerper, CUL7 antikoerper, Cul7 antikoerper
- Hintergrund
- Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 7 is a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin 7 seems to be involved proteosomal degradation of proteins involved in endothelial proliferation and/or differentiation. Cullin 7 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. Cullin 7 interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone.Synonyms: CUL-7, CUL7, KIAA0076
- Gen-ID
- 9820
- NCBI Accession
- NP_001161842
- UniProt
- Q14999
- Pathways
- ER-Nucleus Signaling
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