TRDMT1
Reaktivität: Human
WB
Wirt: Maus
Polyclonal
unconjugated
Applikationshinweise
This product has been assayed by ELISA, Western blotting and Immunoprecipitation. The antibody was tested by ELISA against 0.1 μg of the immunizing peptide. A1/1,000-1/3,000 dilution of the antibody is recommended for this assay. For Western blotting, first Immunoprecipitate (1/100 dilution) the antigen using this
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
1.43 mg/mL (by UV absorbance at 280 nm)
Buffer
0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, containing 0.01 % (w/v) Sodium Azide as preservative.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing. Shelf live: One year from despatch.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Should this product contain a precipitate we recommend microcentrifugation before use.
Target
DNMT3L (TRDMT1)
(DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))
DNMT3L antikoerper, D6Ertd14e antikoerper, ecat7 antikoerper, DNA methyltransferase 3 like antikoerper, DNA (cytosine-5-)-methyltransferase 3-like antikoerper, DNMT3L antikoerper, Dnmt3l antikoerper
Hintergrund
DNMT 3L is a nuclear protein that has similarity to DNA methyltransferases, involved in de novo methylation of CpG islands. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1.Synonyms: DNA (cytosine-5)-methyltransferase 3-like