CD72 Antikörper

Produktnummer ABIN118793

Produktdetails anti-CD72 Antikörper

Target: CD72 (CD72 Molecule (CD72))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD72 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP)

Spezifität: The antibody reacts with CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family).

Aufreinigung: Precipitation methods and ion exchange chromatography

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Normal human lymphocytes from a lymph node

Klon: 3F3

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Immunoprecipitation. Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing. Dilute only prior to immediate use

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CD72

Target: CD72 (CD72 Molecule (CD72))

Andere Bezeichnung: CD72 (CD72 Produkte)

Synonyme: CD72c antikoerper, Ly-19 antikoerper, Ly-32 antikoerper, Ly-m19 antikoerper, Lyb-2 antikoerper, CD72b antikoerper, LYB2 antikoerper, CD72 antigen antikoerper, CD72 molecule antikoerper, Cd72 antikoerper, CD72 antikoerper

Hintergrund: CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation. CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.Synonyms: B-Cell marker, B-cell differentiation antigen CD72, Ly-32, Ly32, Lyb-2, Lymphocyte antigen 32

Gen-ID: 971

NCBI Accession: NP_001773

UniProt: P21854

Pathways: BCR Signaling