This antibody recognizes leukocyte-associated Ig-like receptor-1 (LAIR-1). Clone NKTA255 is reported to inhibit NK cell triggering via CD16 Molecules. We recommend the use of SM2048A for this purpose.
Aufreinigung
Affinity Chromatography on Protein G
Immunogen
NK cells lines B12.100 and AM.25. Remarks: Spleen cells from immunised mice were fused with cells of the P3U1 myeloma cell line.
LAIR-1 is a 40kD cell surface molecule that functions as an inhibitory receptor on natural killer cells, monocytes and T cells. LAIR-1, otherwise known as CD305, is also expressed by other haematopoeitic cells including B cells, but is not expressed by nonhaematopoietic, platelets or erythrocytes.Synonyms: LAIR-1, Leukocyte-associated immunoglobulin-like receptor 1, hLAIR1