SIT1 Antikörper (PE)
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- Target Alle SIT1 Antikörper anzeigen
- SIT1 (Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser SIT1 Antikörper ist konjugiert mit PE
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Applikation
- Flow Cytometry (FACS)
- Spezifität
- The antibody SIT-01 reacts with an intracellular epitope of SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs. It weakly crossreacts with murine SIT.
- Kreuzreaktivität (Details)
- Human
- Aufreinigung
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogen
- Bacterially produced recombinant intracellular fragment of human SIT.
- Klon
- SIT-01
- Isotyp
- IgG1
- Top Product
- Discover our top product SIT1 Primärantikörper
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- Applikationshinweise
- Flow cytometry: Recommended dilution: 1-5 μg/mL. Intracellular staining.
- Kommentare
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.1 mg/mL
- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
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Do not freeze.
Avoid prolonged exposure to light. - Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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- Target
- SIT1 (Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1))
- Andere Bezeichnung
- SIT (SIT1 Produkte)
- Synonyme
- SIT1 antikoerper, RP11-331F9.5 antikoerper, SIT antikoerper, SIT-R antikoerper, Sit antikoerper, signaling threshold regulating transmembrane adaptor 1 antikoerper, suppression inducing transmembrane adaptor 1 antikoerper, SIT1 antikoerper, Sit1 antikoerper
- Hintergrund
- Signaling threshold regulating transmembrane adapt,SIT is a 21 kDa transmembrane adaptor protein expressed exclusively in lymphoid organs. It acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.,SIT1
- Gen-ID
- 27240
- UniProt
- Q9Y3P8
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