Caspase 6 Antikörper (C-Term)

Produktnummer ABIN127060

Produktdetails anti-Caspase 6 Antikörper

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: The antibody detects a full length (35 kDa) and the cleaved fragment (18 kDa) of Caspase-6.

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide mapping to the C-terminus of Rat Caspase-6 large fragment.

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5-4 μg/mL. Jurkat cell lysate, mouse intestine, and rat kidney tissue lysate can be used as a positivecontrols.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: PBS, pH 7.2 containing 30 % Glycero, 0.01 Thimerosal, 0.5 % BSA

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Details zu Caspase 6

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Andere Bezeichnung: Caspase-6 (CASP6 Produkte)

Hintergrund: Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-6 is one of the major executioner caspases functioning in cellular apoptotic processes. Similar as other caspases, caspase-6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase-3, caspase-6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase-6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.Synonyms: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2

Gen-ID: 839

NCBI Accession: NP_001217

UniProt: P55212

Pathways: Apoptose, Caspase Kaskade in der Apoptose