BRCA2
Reaktivität: Human
WB
Wirt: Maus
Monoclonal
1643CT739-91-87
unconjugated
Applikationshinweise
Western Blot: 0.5-4 μg/mL. HeLa cell lysate can be used as a Positive Control. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
BRCA 1 and 2 are breast cancer susceptibility proteins that plays a role in DNA damage, repair, cell cycle progression, transcription and apoptosis, etc. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. BRCA2 has been shown to be required for localization of Rad51 to sites of DSBs (double stranded breaks) in DNA. Cells lacking BRCA1 and BRCA2 cannot repair DSBs through the Rad51-dependent process.Synonyms: Breast cancer type 2 susceptibility protein, FACD, Fanconi anemia group D1 protein