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ING3 Antikörper (AA 285-310)

Rockland 600-101-283 ING3 Reaktivität: Human WB, ELISA Wirt: Ziege Polyclonal unconjugated
Rockland
Produktnummer ABIN129551
Hersteller Produkt- Nr.: 600-101-283
  • Target Alle ING3 Antikörper anzeigen
    ING3 (Inhibitor of Growth Family, Member 3 (ING3))
    Bindungsspezifität
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 285-310
    Reaktivität
    • 31
    • 20
    • 17
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 27
    • 4
    Ziege
    Klonalität
    • 28
    • 3
    Polyklonal
    Konjugat
    • 20
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ING3 Antikörper ist unkonjugiert
    Applikation
    • 19
    • 12
    • 9
    • 5
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Hersteller Produkt- Nr.
    600-101-283
    Hersteller
    Rockland
    Verwendungszweck
    p47ING3 Antibody
    Kreuzreaktivität (Details)
    Reactivity occurs against human p47 ING3 protein.
    Produktmerkmale
    Synonyms: goat anti-p47 ING3 antibody, p47ING3, ING-3, ING 3, Inhibitor of growth family member 3 antibody, Inhibitor of growth protein 3 antibody
    Aufreinigung
    This is an affinity-purified antibody produced by immunoaffinity chromatography using the immunizing peptide after immobilization to a solid phase.
    Sterilität
    Sterile filtered
    Immunogen

    Immunogen: This affinity purified antibody was prepared from whole Goat serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near aa 285-310 of Human ING3 protein (Inhibitor of growth family, member 3).

    Immunogen Type: Conjugated Peptide

    Isotyp
    IgG
    Top Product
    Discover our top product ING3 Primärantikörper
  • Applikationshinweise

    Application Note: This affinity purified antibody has been tested for use in ELISA against the immunizing peptide. Specific conditions for western blotting reactivity should be optimized by the end user.  Expect a band at approximately 47 kDa in size corresponding to ING3 isoform 1 by western blotting in the appropriate cell lysate or extract.

    Western Blot Dilution: 1:200 - 1:2,000

    ELISA Dilution: 1:10,000 - 1:40,000

    Other: User Optimized

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.10 mg/mL
    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    Haltbarkeit
    12 months
  • Target
    ING3 (Inhibitor of Growth Family, Member 3 (ING3))
    Andere Bezeichnung
    ING3 (ING3 Produkte)
    Hintergrund
    Background: p47 ING3 is a tumor suppressor protein similar to ING1 that  can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Over-expression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Multiple alternatively spliced transcript variants have been observed.  The accession number listed below is for variant (1) that encodes the longest isoform.
    Gen-ID
    54556, 38201655
    UniProt
    Q9NXR8
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