PLK1 Antikörper (pThr210)

Produktnummer ABIN129581

Produktdetails anti-PLK1 Antikörper

Target: PLK1 (Polo-Like Kinase 1 (PLK1))

Bindungsspezifität: AA 205-214, pThr210

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Aufreinigung: This product is an affinity purified antibody produced by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Immunogen: Anti-Polo-like Kinase pT210 Antibody was produced by repeated immunizations with a synthetic phospho peptide corresponding to aa 205-214 of Human Polo-like kinase 1 (Plk1) protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity-purified antibody has been tested for use in ELISA, IHC and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 68 kDa in size corresponding to Plk-1 by western blotting in the appropriate cell lysate or extract.   This antibody is positive by IHC on kidney, liver, cancer, thyroid and lymphocyte tissue.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-PLK1 Antikörper (ABIN129581)

Adler, Müller, Rached, Dekant, Mally: "Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity." in: Carcinogenesis, Vol. 30, Issue 4, pp. 711-9, (2009) (PubMed).

Details zu PLK1

Target: PLK1 (Polo-Like Kinase 1 (PLK1))

Andere Bezeichnung: Plk1 (PLK1 Produkte)

Synonyme: PLK antikoerper, STPK13 antikoerper, plk antikoerper, PLK-1 antikoerper, Plx1 antikoerper, stpk13 antikoerper, Plk antikoerper, cb525 antikoerper, cb636 antikoerper, ik:tdsubc_2d1 antikoerper, wu:fb37g11 antikoerper, wu:fb76g03 antikoerper, xx:tdsubc_2d1 antikoerper, polo like kinase 1 antikoerper, polo like kinase 1 S homeolog antikoerper, polo-like kinase 1 antikoerper, polo-like kinase 1 (Drosophila) antikoerper, Serine/threonine-protein kinase plk-1 antikoerper, PLK1 antikoerper, plk1.S antikoerper, plk1 antikoerper, Plk1 antikoerper, plk-1 antikoerper

Hintergrund: Polo-like Kinase pT210 Antibody detects phosphorylated Plk1 protein. Polo-like kinase 1, also known as Plk-1, serine-threonine protein kinase 13 and STPK13, may be required for cell division and have a role during G₁ or S phase and is associated with the phosphorylation of cyclin B₁.  Phosphorylation of Plk-1 on T210 contributes to proper mitotic progression.  Plk-1 has a nuclear localization and accumulates to a maximum during the G₂ and M phases, declines to a nearly undetectable level following mitosis and throughout G₁ phase, and then begins to accumulate again during S phase.  Plk-1 is a member of the Ser/Thr protein kinase family and the CDC5/Polo subfamily and contains 2 POLO box domains.
Synonyms: PLK 1 antibody, PLK antibody, polio like kinase antibody, Polo like kinase 1 antibody, Polo-like kinase 1 antibody, Serine/threonine protein kinase 13 antibody

Gen-ID: 5347, 21359873

UniProt: P53350

Pathways: Zellzyklus, M Phase