FANCA Antikörper (AA 995-1009)

Produktnummer ABIN129606

Hersteller Produkt- Nr.: 600-401-670

Produktdetails anti-FANCA Antikörper

Target: FANCA (Fanconi Anemia Group A Protein (FANCA))

Bindungsspezifität: AA 995-1009

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FANCA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Hersteller Produkt- Nr.: 600-401-670

Hersteller: Rockland

Verwendungszweck: FANCA Antibody

Kreuzreaktivität (Details): This affinity-purified antibody is directed against human FANCA protein.

Produktmerkmale: Synonyms: rabbit anti-FANCA antibody, FANC-A, FANC A, Fanconi anemia group A protein, FAA antibody, FACA antibody, FAH antibody, FANCH antibody

Aufreinigung: The product was affinity purified from monospecific antiserum by immunoaffinity purification.

Sterilität: Sterile filtered

Immunogen:

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 995-1009 of human FANCA protein.

Immunogen Type: Conjugated Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Application Note: This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a main band at approximately 163 kDa in size corresponding to FANCA by western blotting in the appropriate cell lysate or extract or human tissue.

Western Blot Dilution: 1:500 - 1:3,000

ELISA Dilution: 1:15,000 - 1:60,000

Other: User Optimized

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2.2 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Referenzen für anti-FANCA Antikörper (ABIN129606)

Smogorzewska, Matsuoka, Vinciguerra, McDonald, Hurov, Luo, Ballif, Gygi, Hofmann, DAndrea, Elledge: "Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair." in: Cell, Vol. 129, Issue 2, pp. 289-301, (2007) (PubMed).

Details zu FANCA

Target: FANCA (Fanconi Anemia Group A Protein (FANCA))

Andere Bezeichnung: FANCA (FANCA Produkte)

Hintergrund: Background: FANCA (also called Protein FACA or Fanconi anemia group A protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCA may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.  The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Diseases associated with FANCA include Fanconi anemia complementation group a and Congenital Hypoplastic Anemia.

Gen-ID: 2175, 66880553

UniProt: O15360

Pathways: DNA Reparatur