FANCC Antikörper (AA 80-115)

Produktnummer ABIN129608

Hersteller Produkt- Nr.: 600-401-672

Produktdetails anti-FANCC Antikörper

Target: FANCC (Fanconi Anemia, Complementation Group C (FANCC))

Bindungsspezifität: AA 80-115

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FANCC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Hersteller Produkt- Nr.: 600-401-672

Hersteller: Rockland

Verwendungszweck: FANCC Antibody

Kreuzreaktivität (Details): This affinity-purified antibody is directed against human FANCC protein.

Produktmerkmale: Synonyms: rabbit anti-FANCC antibody, FANC-C, FANC C, FAC antibody, FACC antibody, Fanconi anemia group C protein, Fanconi anemia complementation group C antibody

Aufreinigung: The product was affinity purified from monospecific antiserum by immunoaffinity purification.

Sterilität: Sterile filtered

Immunogen:

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 80-115 of Human FANCC.

Immunogen Type: Conjugated Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Application Note: This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 63 kDa in size corresponding to FANCC by western blotting in the appropriate human tissue.

Western Blot Dilution: 1:1,000 - 1:3,000

ELISA Dilution: 1:20,000 - 1:80,000

Other: User Optimized

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.45 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu FANCC

Target: FANCC (Fanconi Anemia, Complementation Group C (FANCC))

Andere Bezeichnung: FANCC (FANCC Produkte)

Hintergrund: Background: FANCC (also called Protein FACC or Fanconi Anemia Group C protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function.  FANCC may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.  FANCC belongs to the multi-subunit Fanconi Anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM.  FANCC is mainly found within the nucleus although some protein is localized in the cytoplasm.  This protein is ubiquitously expressed.  Defects in FANCC are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C.

Gen-ID: 2176, 56118236

UniProt: Q00597

Pathways: DNA Reparatur